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Imidafenacin

Name: Imidafenacin
Brand: TargetMol
SKU: T4986
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4986Cas No. 170105-16-5

Alias ONO-8025, KRP-197

Imidafenacin (KRP-197)(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM.

Imidafenacin

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Purity: 99.17%

Catalog No. T4986Alias ONO-8025, KRP-197Cas No. 170105-16-5

Imidafenacin (KRP-197)(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM.

Pack Size	Price	Availability
25 mg	$52	In Stock
50 mg	$79	In Stock
100 mg	$118	In Stock
500 mg	$298	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.17%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Imidafenacin (KRP-197)(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM.
Targets&IC50	M3:0.3 nM
Synonyms	ONO-8025, KRP-197

Chemical Properties

Molecular Weight	319.4
Formula	C₂₀H₂₁N₃O
Cas No.	170105-16-5
Smiles	Cc1nccn1CCC(C(N)=O)(c1ccccc1)c1ccccc1
Relative Density.	1.12g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (203.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1309 mL	15.6544 mL	31.3087 mL	156.5435 mL
5 mM	0.6262 mL	3.1309 mL	6.2617 mL	31.3087 mL
10 mM	0.3131 mL	1.5654 mL	3.1309 mL	15.6544 mL
20 mM	0.1565 mL	0.7827 mL	1.5654 mL	7.8272 mL
50 mM	0.0626 mL	0.3131 mL	0.6262 mL	3.1309 mL
100 mM	0.0313 mL	0.1565 mL	0.3131 mL	1.5654 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc