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CMP8

Name: CMP8
Brand: TargetMol
SKU: T14987
Price: 152 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14987Cas No. 851107-28-3

CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively.

CMP8

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Purity: 99.36%

Catalog No. T14987Cas No. 851107-28-3

Pack Size	Price	Availability
1 mg	$152	In Stock
5 mg	$312	In Stock
10 mg	$446	In Stock
25 mg	$690	In Stock
50 mg	$930	In Stock
100 mg	$1,180	In Stock
200 mg	$1,580	In Stock
1 mL x 10 mM (in DMSO)	$391	In Stock

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Purity:99.36%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively.
Targets&IC50	MGERα:29 nM, MGRERα:41 nM, ERβ (human):2200 nM, ERα (human):1100 nM
In vivo	CMP8 is dosed in male Balb-c mice (4 mg/kg, ip). In mammalian cells, the plasma concentration after 4 h is 1.5-fold its EC50. It has a Cmax of 0.5 μM after 30 min.[1][2]

Chemical Properties

Molecular Weight	528.08
Formula	C₃₃H₃₄ClNO₃
Cas No.	851107-28-3
Smiles	C(C12C(C=3C(C1)=CC(O)=CC3)=C(C(=O)CC2)C4=CC=C(OCCN5CCCCC5)C=C4)C6=CC=C(Cl)C=C6
Relative Density.	1.30 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (94.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8937 mL	9.4683 mL	18.9365 mL	94.6826 mL
5 mM	0.3787 mL	1.8937 mL	3.7873 mL	18.9365 mL
10 mM	0.1894 mL	0.9468 mL	1.8937 mL	9.4683 mL
20 mM	0.0947 mL	0.4734 mL	0.9468 mL	4.7341 mL
50 mM	0.0379 mL	0.1894 mL	0.3787 mL	1.8937 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc