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MKC9989

Name: MKC9989
Brand: TargetMol
SKU: T12071
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12071Cas No. 1338934-20-5

MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM.

MKC9989

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Purity: 99.3%

Catalog No. T12071Cas No. 1338934-20-5

MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM.

Pack Size	Price	Availability
1 mg	$47	In Stock
5 mg	$158	In Stock
10 mg	$238	In Stock
25 mg	$396	In Stock
50 mg	$572	In Stock
100 mg	$768	In Stock
1 mL x 10 mM (in DMSO)	$143	In Stock

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Batch Information

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Purity:99.3%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM.
Targets&IC50	IRE1α:0.23 to 44 μM
In vitro	MKC9989, significantly stabilizes the RIDD target CD59 mRNA when co-administered with thapsigargin relative to thapsigargin treatment alone and modestly increases levels of CD59 mRNA in non-stressed cells, the latter likely reflects the inhibition of baseline RIDD activity. In contrast to effects on XBP1 splicing, MKC9989 moderately stabilizes CD59 levels when administered 2 hour post treatment with thapsigargin.[1].

Chemical Properties

Molecular Weight	336.34
Formula	C₁₇H₂₀O₇
Cas No.	1338934-20-5
Smiles	COCCOCCc1c(C)c2cc(OC)c(O)c(C=O)c2oc1=O
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 49 mg/mL (145.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9732 mL	14.8659 mL	29.7318 mL	148.6591 mL
5 mM	0.5946 mL	2.9732 mL	5.9464 mL	29.7318 mL
10 mM	0.2973 mL	1.4866 mL	2.9732 mL	14.8659 mL
20 mM	0.1487 mL	0.7433 mL	1.4866 mL	7.4330 mL
50 mM	0.0595 mL	0.2973 mL	0.5946 mL	2.9732 mL
100 mM	0.0297 mL	0.1487 mL	0.2973 mL	1.4866 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc