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SB-265610

Name: SB-265610
Brand: TargetMol
SKU: T16850
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16850Cas No. 211096-49-0

Alias GSK-CXCR2

SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and 70 nM, respectively).

SB-265610

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Purity: 99.5%

Catalog No. T16850Alias GSK-CXCR2Cas No. 211096-49-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$396	In Stock	In Stock
50 mg	$589	In Stock	In Stock
100 mg	$843	In Stock	In Stock
500 mg	$1,730	In Stock	-
1 mL x 10 mM (in DMSO)	$133	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.5%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and 70 nM, respectively).
Targets&IC50	CXCR2 (neutrophil chemotaxis):70 nM, CXCR2 (CINC-1-induced calcium mobilization):3.7 nM
In vitro	SB-265610 decreases the antiapoptotic effect of CINC-1 to the levels of those untreated with CINC-1. SB-265610 antagonizes rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization (IC50 of 3.7 nM) and rat neutrophil chemotaxis in a concentration-dependent manner (IC50 of 70 nM) [1].
In vivo	SB-265610 (100 mg/kg/day;p.o; daily; for 5 days; CXCR2 wild type mice) treatment markedly delays healing parameters in CXCR2 wild type mice during the wound repair process[2].
Synonyms	GSK-CXCR2

Chemical Properties

Molecular Weight	357.16
Formula	C₁₄H₉BrN₆O
Cas No.	211096-49-0
Smiles	Brc1ccccc1NC(=O)Nc1ccc(C#N)c2nn[nH]c12
Relative Density.	1.77 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 66 mg/mL (184.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7999 mL	13.9993 mL	27.9987 mL	139.9933 mL
5 mM	0.5600 mL	2.7999 mL	5.5997 mL	27.9987 mL
10 mM	0.2800 mL	1.3999 mL	2.7999 mL	13.9993 mL
20 mM	0.1400 mL	0.7000 mL	1.3999 mL	6.9997 mL
50 mM	0.0560 mL	0.2800 mL	0.5600 mL	2.7999 mL
100 mM	0.0280 mL	0.1400 mL	0.2800 mL	1.3999 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc