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GYKI 52466 dihydrochloride

🥰Excellent
Catalog No. T11522Cas No. 2319722-40-0
Alias GYKI-52466 dihydrochloride, GYKI52466 dihydrochloride, GYKI 52466 2HCl

GYKI 52466 dihydrochloride (GYKI 52466 2HCl) is a highly potent, orally active and selective AMPA/Kainate receptor antagonist with good blood-brain permeability and anticonvulsant activity that can be used to study neurological diseases such as Parkinson's and epilepsy.

GYKI 52466 dihydrochloride
Other Forms of GYKI 52466 dihydrochloride:

GYKI 52466 dihydrochloride

🥰Excellent
Purity: 99.38%
Catalog No. T11522Alias GYKI-52466 dihydrochloride, GYKI52466 dihydrochloride, GYKI 52466 2HClCas No. 2319722-40-0
GYKI 52466 dihydrochloride (GYKI 52466 2HCl) is a highly potent, orally active and selective AMPA/Kainate receptor antagonist with good blood-brain permeability and anticonvulsant activity that can be used to study neurological diseases such as Parkinson's and epilepsy.
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2 mg$99In Stock
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Purity:99.38%
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Product Introduction

Bioactivity
Description
GYKI 52466 dihydrochloride (GYKI 52466 2HCl) is a highly potent, orally active and selective AMPA/Kainate receptor antagonist with good blood-brain permeability and anticonvulsant activity that can be used to study neurological diseases such as Parkinson's and epilepsy.
Targets&IC50
AMPA receptor:11 μM , Kainate receptor:7.5 μM
In vitro
In cultured rat hippocampal neurons, GYKI 52466 dihydrochloride (0.3-100 μM) was able to inhibit inward currents activated by AMPA and Kainate receptors. [1]
In vivo
GYKI 52466 dihydrochloride (1.76-13.2 mg/kg; single administration), given by intraperitoneal injection to DBA/2 mice, was able to provide effective anticonvulsant protection against sound-induced seizures. [2]
SynonymsGYKI-52466 dihydrochloride, GYKI52466 dihydrochloride, GYKI 52466 2HCl
Chemical Properties
Molecular Weight366.24
FormulaC17H17Cl2N3O2
Cas No.2319722-40-0
SmilesCC1=NN=C(C2=CC=C(N)C=C2)C3=C(C=C4OCOC4=C3)C1.Cl.Cl
Relative Density.no data available
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 1 mg/mL(2.73 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7304 mL13.6522 mL27.3045 mL136.5225 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Kainate receptorGYKI-52466GYKI52466GYKI 52466 dihydrochlorideGYKI 52466AMPA receptorAMPA
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