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GYKI 52466 dihydrochloride
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Catalog No. T11522Cas No. 2319722-40-0
Alias GYKI-52466 dihydrochloride, GYKI52466 dihydrochloride, GYKI 52466 2HCl
GYKI 52466 dihydrochloride (GYKI 52466 2HCl) is a highly potent, orally active and selective AMPA/Kainate receptor antagonist with good blood-brain permeability and anticonvulsant activity that can be used to study neurological diseases such as Parkinson's and epilepsy.
GYKI 52466 dihydrochloride
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Purity: 99.38%
Catalog No. T11522Alias GYKI-52466 dihydrochloride, GYKI52466 dihydrochloride, GYKI 52466 2HClCas No. 2319722-40-0
GYKI 52466 dihydrochloride (GYKI 52466 2HCl) is a highly potent, orally active and selective AMPA/Kainate receptor antagonist with good blood-brain permeability and anticonvulsant activity that can be used to study neurological diseases such as Parkinson's and epilepsy.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $99 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.38%
Appearance:Solid
Color:Yellow
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| Description | GYKI 52466 dihydrochloride (GYKI 52466 2HCl) is a highly potent, orally active and selective AMPA/Kainate receptor antagonist with good blood-brain permeability and anticonvulsant activity that can be used to study neurological diseases such as Parkinson's and epilepsy. |
| Targets&IC50 | Kainate receptor:7.5 μM , AMPA receptor:11 μM |
| In vitro | In cultured rat hippocampal neurons, GYKI 52466 dihydrochloride (0.3-100 μM) was able to inhibit inward currents activated by AMPA and Kainate receptors. [1] |
| In vivo | GYKI 52466 dihydrochloride (1.76-13.2 mg/kg; single administration), given by intraperitoneal injection to DBA/2 mice, was able to provide effective anticonvulsant protection against sound-induced seizures. [2] |
| Synonyms | GYKI-52466 dihydrochloride, GYKI52466 dihydrochloride, GYKI 52466 2HCl |
| Molecular Weight | 366.24 |
| Formula | C17H17Cl2N3O2 |
| Cas No. | 2319722-40-0 |
| Smiles | CC1=NN=C(C2=CC=C(N)C=C2)C3=C(C=C4OCOC4=C3)C1.Cl.Cl |
| Relative Density. | no data available |
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (2.73 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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