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TCO-NHS ester

Name: TCO-NHS ester
Brand: TargetMol
SKU: T17014
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17014Cas No. 1191901-33-3

TCO-NHS ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-NHS ester

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Purity: 99.86%

Catalog No. T17014Cas No. 1191901-33-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
5 mg	$86	In Stock	In Stock
10 mg	$126	In Stock	In Stock
25 mg	$209	In Stock	In Stock
50 mg	$313	In Stock	In Stock
100 mg	$493	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TCO-NHS ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
In vitro	PROTACs consist of two linked ligands: one binding to an E3 ubiquitin ligase and the other to the target protein. They exploit the ubiquitin-proteasome system to selectively degrade target proteins [1].

Chemical Properties

Molecular Weight	267.28
Formula	C₁₃H₁₇NO₅
Cas No.	1191901-33-3
Smiles	O=C(OC1CCCC=CCC1)ON1C(=O)CCC1=O
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (561.21 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7414 mL	18.7070 mL	37.4139 mL	187.0697 mL
5 mM	0.7483 mL	3.7414 mL	7.4828 mL	37.4139 mL
10 mM	0.3741 mL	1.8707 mL	3.7414 mL	18.7070 mL
20 mM	0.1871 mL	0.9353 mL	1.8707 mL	9.3535 mL
50 mM	0.0748 mL	0.3741 mL	0.7483 mL	3.7414 mL
100 mM	0.0374 mL	0.1871 mL	0.3741 mL	1.8707 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc