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RG7800 hydrochloride (1449598-06-4 free base)
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Catalog No. T12718
Alias RO6885247 hydrochloride, RG7800 hydrochloride
RG7800 hydrochloride is an orally active modulator of SMN2 splicing.
RG7800 hydrochloride (1449598-06-4 free base)
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Catalog No. T12718Alias RO6885247 hydrochloride, RG7800 hydrochloride
RG7800 hydrochloride is an orally active modulator of SMN2 splicing.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $108 | Inquiry | Inquiry | |
| 10 mg | $171 | Inquiry | Inquiry | |
| 50 mg | $584 | Inquiry | Inquiry | |
| 100 mg | $873 | Inquiry | Inquiry | |
| 200 mg | Inquiry | Inquiry | Inquiry | |
| 500 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | RG7800 hydrochloride is an orally active modulator of SMN2 splicing. |
| Targets&IC50 | SMN protein:, SMN2 splicing: 87 nM , EC1.5x: 23 nM |
| In vitro | RG7800 hydrochloride is an orally active modulator of SMN2 splicing(EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein).RG7800 hydrochloride is the first small molecule SMN2 splicing modifier to enter human clinical trials. |
| In vivo | RG7800 dose-dependently elevates the SMN protein level in the brain and in peripheral tissue of Δ7 mice. RG7800 is a favorable agent metabolism and pharmacokinetic (DMPK) profile in the rat and in cynomolgus monkey with good oral bioavailability. |
| Synonyms | RO6885247 hydrochloride, RG7800 hydrochloride |
| Formula | C24H28N6O.xHCl |
| Smiles | CC1=CC(C2CCN(C)CC2)=CN3C1=NC(C4=NN(C=C(C)N=C5CC)C5=C4)=CC3=O.[xHCl] |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 113.5 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
SMN2 splicingSMN proteinRO-6885247 HydrochlorideRO6885247 HydrochlorideRO 6885247 HydrochlorideRG-7800 hydrochloride (1449598-06-4 free base)RG7800 hydrochloride (1449598064 free base)RG7800 hydrochloride (1449598 06 4 free base)RG-7800 HydrochlorideRG7800 HydrochlorideRG 7800 HydrochlorideEC1.5x1449598-06-4 free base1449598-06-4
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