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Bromfenac Sodium

Name: Bromfenac Sodium
Brand: TargetMol
SKU: T6424
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6424Cas No. 91714-93-1

Alias Bronuck, AHR 10282R, AHR 10282B

Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.

Bromfenac Sodium

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Purity: 99.93%

Catalog No. T6424Alias Bronuck, AHR 10282R, AHR 10282BCas No. 91714-93-1

Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$36	In Stock	In Stock
50 mg	$56	In Stock	In Stock
100 mg	$73	In Stock	In Stock
500 mg	$178	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bromfenac Sodium AI Summary

Bromfenac Sodium exhibits context-dependent bioactivity, impacting cell viability and protein stability variably across different conditions. In HEK293T cells, it shows mixed effects on growth rates (0.43, -0.53, 0.98), while consistently enhancing growth in U2OS cells with rates ranging from 0.2 to 0.95. Conversely, it negatively affects human fibroblast cell growth with a rate of -0.66. Additionally, Bromfenac Sodium influences the thermal stability of various protein domains, stabilizing some (positive Delta TM values) and destabilizing others (negative Delta TM values). These findings indicate that Bromfenac Sodium's effects are highly dependent on the specific biological context..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
Targets&IC50	COX-2:7.45 nM (IC50), COX-1:5.56 nM (IC50)
Synonyms	Bronuck, AHR 10282R, AHR 10282B

Chemical Properties

Molecular Weight	356.15
Formula	C₁₅H₁₁BrNO₃·Na
Cas No.	91714-93-1
Smiles	[Na+].NC1=C(C=CC=C1CC([O-])=O)C(=O)C1=CC=C(Br)C=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 65 mg/mL (182.51 mM), Sonication is recommended.

Ethanol: 2 mg/mL (5.62 mM), Sonication is recommended.

DMSO: 55 mg/mL (154.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8078 mL	14.0390 mL	28.0781 mL	140.3903 mL
5 mM	0.5616 mL	2.8078 mL	5.6156 mL	28.0781 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
10 mM	0.2808 mL	1.4039 mL	2.8078 mL	14.0390 mL
20 mM	0.1404 mL	0.7020 mL	1.4039 mL	7.0195 mL
50 mM	0.0562 mL	0.2808 mL	0.5616 mL	2.8078 mL
100 mM	0.0281 mL	0.1404 mL	0.2808 mL	1.4039 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc