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5-Hydroxymethyl-2'-deoxycytidine

🥰Excellent
Catalog No. T40834Cas No. 7226-77-9
Alias 5hmdC

5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations, replication fork damage, and loss of cell viability.5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine in DNA. Hydroxymethyl-2'-deoxycytidine replication fork instability is associated with the presence of poly(ADP-ribose) polymerase 1 (PARP1) on chromatin.

5-Hydroxymethyl-2'-deoxycytidine

5-Hydroxymethyl-2'-deoxycytidine

🥰Excellent
Purity: 99.8%
Catalog No. T40834Alias 5hmdCCas No. 7226-77-9
5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations, replication fork damage, and loss of cell viability.5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine in DNA. Hydroxymethyl-2'-deoxycytidine replication fork instability is associated with the presence of poly(ADP-ribose) polymerase 1 (PARP1) on chromatin.
Pack SizePriceAvailabilityQuantity
1 mg$34In Stock
5 mg$80In Stock
10 mg$122In Stock
25 mg$213In Stock
50 mg$339In Stock
100 mg$513In Stock
500 mg$1,090In Stock
1 mL x 10 mM (in DMSO)$89In Stock
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Purity:99.8%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations, replication fork damage, and loss of cell viability.5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine in DNA. Hydroxymethyl-2'-deoxycytidine replication fork instability is associated with the presence of poly(ADP-ribose) polymerase 1 (PARP1) on chromatin.
Synonyms5hmdC
Chemical Properties
Molecular Weight257.24
FormulaC10H15N3O5
Cas No.7226-77-9
SmilesNc1nc(=O)n(cc1CO)[C@H]1C[C@H](O)[C@@H](CO)O1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (174.93 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8874 mL19.4371 mL38.8742 mL194.3710 mL
5 mM0.7775 mL3.8874 mL7.7748 mL38.8742 mL
10 mM0.3887 mL1.9437 mL3.8874 mL19.4371 mL
20 mM0.1944 mL0.9719 mL1.9437 mL9.7186 mL
50 mM0.0777 mL0.3887 mL0.7775 mL3.8874 mL
100 mM0.0389 mL0.1944 mL0.3887 mL1.9437 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

PARP15Hydroxymethyl2'deoxycytidine5-Hydroxymethyl-2'-deoxycytidine5 Hydroxymethyl 2' deoxycytidine
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