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CH-5132799 Mesylate
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Catalog No. T202301Cas No. 2242053-82-1
Alias PA-799 mesylate, IZORLISIB MESYLATE, IZORLISIB MESILATE, CH5132799 Mesylate, CH-5132799 Mesilate, CH 5132799 Mesylate PA 799 mesylate
CH5132799 (also known as PA-799) is a novel class I PI3K inhibitor, exhibiting potent inhibition of PI3Kα with an IC(50) of 0.014 μM. This compound demonstrates significant antiproliferative effects on human tumor cell lines with an activated PI3K pathway. Administrable orally, CH5132799 shows notable antitumor activity in human cancer xenograft mouse models where the PI3K pathway is activated. It specifically inhibits class I PI3K and PI3Kα mutants, as confirmed by in vitro kinase assays. Tumors harboring the PIK3CA mutation are highly sensitive to CH5132799 in vitro and are significantly regressed in in vivo mouse xenograft models.
CH-5132799 Mesylate
😃Good
Catalog No. T202301Alias PA-799 mesylate, IZORLISIB MESYLATE, IZORLISIB MESILATE, CH5132799 Mesylate, CH-5132799 Mesilate, CH 5132799 Mesylate PA 799 mesylateCas No. 2242053-82-1
CH5132799 (also known as PA-799) is a novel class I PI3K inhibitor, exhibiting potent inhibition of PI3Kα with an IC(50) of 0.014 μM. This compound demonstrates significant antiproliferative effects on human tumor cell lines with an activated PI3K pathway. Administrable orally, CH5132799 shows notable antitumor activity in human cancer xenograft mouse models where the PI3K pathway is activated. It specifically inhibits class I PI3K and PI3Kα mutants, as confirmed by in vitro kinase assays. Tumors harboring the PIK3CA mutation are highly sensitive to CH5132799 in vitro and are significantly regressed in in vivo mouse xenograft models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CH5132799 (also known as PA-799) is a novel class I PI3K inhibitor, exhibiting potent inhibition of PI3Kα with an IC(50) of 0.014 μM. This compound demonstrates significant antiproliferative effects on human tumor cell lines with an activated PI3K pathway. Administrable orally, CH5132799 shows notable antitumor activity in human cancer xenograft mouse models where the PI3K pathway is activated. It specifically inhibits class I PI3K and PI3Kα mutants, as confirmed by in vitro kinase assays. Tumors harboring the PIK3CA mutation are highly sensitive to CH5132799 in vitro and are significantly regressed in in vivo mouse xenograft models. |
| Synonyms | PA-799 mesylate, IZORLISIB MESYLATE, IZORLISIB MESILATE, CH5132799 Mesylate, CH-5132799 Mesilate, CH 5132799 Mesylate PA 799 mesylate |
| Molecular Weight | 473.53 |
| Formula | C16H23N7O6S2 |
| Cas No. | 2242053-82-1 |
| Smiles | O=S(=O)(O)C.O=S(=O)(N1C2=NC(=NC(C3=CN=C(N=C3)N)=C2CC1)N4CCOCC4)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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