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Cephalomannine

Name: Cephalomannine
Brand: TargetMol
SKU: T2217
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2217Cas No. 71610-00-9

Alias Baccatin III

Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.

Cephalomannine

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Purity: 99.94%

Catalog No. T2217Alias Baccatin IIICas No. 71610-00-9

Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$43	In Stock	In Stock
25 mg	$67	In Stock	In Stock
50 mg	$95	In Stock	In Stock
100 mg	$138	In Stock	In Stock
500 mg	$339	-	In Stock
1 mL x 10 mM (in DMSO)	$60	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Color:White

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COA LCMS HNMR

Product Introduction

Cephalomannine AI Summary

Cephalomannine exhibits a binding affinity to microtubules, with an activity expressed as an ID50 ratio of 1.5 compared to paclitaxel. It demonstrates broad cytotoxic and antiproliferative activity against various human cancer cell lines, including MCF7, HCT8, Bel7402, BGC823, A549, A2780, and KB cells, with IC50 values ranging from 4.0 nM to 920.0 nM. Specifically, it shows potent cytotoxicity against human MCF7 cells with an IC50 of 6.0 nM after 72 hours and KB cells with an ED50 of 3.8 x 10^-3 ug/mL. Cephalomannine also exhibits in vivo antitumor activity against mouse P388 cells at doses of 1 to 3.3 mg/kg, with a Tumor Control (T/C) value of up to 162.0%. Furthermore, it induces tubulin assembly in bovine brain at specific concentrations, with ED50 values of 0.95 uM and 0.85 uM, indicating its mechanism of action is comparable to Taxol. The compound also shows toxicity on brine shrimp with an LC50 of 0.81 ug/mL after 24 hours. Additionally, it has demonstrated antiproliferative effects against mouse NIH/3T3 cells with an IC50 of 600.0 nM and reduced efficacy against A2780/TAX, HCT8, and HCT8/VCT cell lines..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.
Synonyms	Baccatin III

Chemical Properties

Molecular Weight	831.9
Formula	C₄₅H₅₃NO₁₄
Cas No.	71610-00-9
Smiles	C\C=C(/C)C(=O)N[C@H]([C@@H](O)C(=O)O[C@H]1C[C@@]2(O)[C@@H](OC(=O)c3ccccc3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C(=O)[C@H](OC(C)=O)C(=C1C)C2(C)C)OC(C)=O)c1ccccc1
Relative Density.	1.36 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 93 mg/mL (111.79 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (111.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (3.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.2021 mL	6.0103 mL	12.0207 mL	60.1034 mL
5 mM	0.2404 mL	1.2021 mL	2.4041 mL	12.0207 mL
10 mM	0.1202 mL	0.6010 mL	1.2021 mL	6.0103 mL
20 mM	0.0601 mL	0.3005 mL	0.6010 mL	3.0052 mL
50 mM	0.0240 mL	0.1202 mL	0.2404 mL	1.2021 mL
100 mM	0.0120 mL	0.0601 mL	0.1202 mL	0.6010 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc