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EK1 sodium salt

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Catalog No. TP3707L Copy Product Info
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EK1 sodium salt is a broad-spectrum coronavirus fusion inhibitor that targets the HR1 domain of the viral S protein, blocking fusion between the virus and the host cell membrane and thereby inhibiting viral entry. In vitro, EK1 sodium salt has demonstrated inhibitory activity against a variety of β-coronaviruses and is commonly used in studies of viral infection mechanisms and antiviral drug screening.
EK1 sodium salt
Other Forms of EK1 sodium salt:
EK1TP3707
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Product Introduction

Bioactivity
Description
EK1 sodium salt is a broad-spectrum coronavirus fusion inhibitor that targets the HR1 domain of the viral S protein, blocking fusion between the virus and the host cell membrane and thereby inhibiting viral entry. In vitro, EK1 sodium salt has demonstrated inhibitory activity against a variety of β-coronaviruses and is commonly used in studies of viral infection mechanisms and antiviral drug screening.
Chemical Properties
Molecular Weight4353.97
FormulaC196H316N43NaO64S
Smiles[H]N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@](C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@H](C(N[C@](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C([O-])=O)=O)=O)=O)=O)CC(O)=O)=O)([C@H](CC)C)[H])=O)CC1=CC=C(O)C=C1)=O)=O)=O)=O)=O)=O)=O)([C@H](CC)C)[H])=O)C)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)CC2=CC=C(O)C=C2)=O)=O)=O)CC(O)=O)=O)=O)CC3=CC=CC=C3)=O)([C@@H](C)O)[H])=O)=O)=O)([C@H](CC)C)[H])=O)=O)CC(O)=O)=O)=O.[Na+]
Relative Density.no data available
SequenceSer-Leu-Asp-Gln-Ile-Asn-Val-Thr-Phe-Leu-Asp-Leu-Glu-Tyr-Glu-Met-Lys-Lys-Leu-Glu-Glu-Ala-Ile-Lys-Lys-Leu-Glu-Glu-Ser-Tyr-Ile-Asp-Leu-Lys-Glu-Leu
Sequence ShortSLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKEL
Storage & Solubility Information
StorageKeep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

EK1sodiumsalt
Related Tags: EK1 sodium salt chemical structure | EK1 sodium salt formula | EK1 sodium salt molecular weight
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