Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-didesmethyl Loperamide, an active metabolite of the peripheral μ1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated guinea pig myenteric plexus (IC50 = 370 nM) and enhances the sensitivity of a chloroquine-resistant P. falciparum strain to chloroquine (EC50 = 482 nM). Notably, it achieves this without causing toxicity in A-10 vascular smooth muscle cells (IC50 = <10,000 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 448.00 |
Description | N-didesmethyl Loperamide, an active metabolite of the peripheral μ1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated guinea pig myenteric plexus (IC50 = 370 nM) and enhances the sensitivity of a chloroquine-resistant P. falciparum strain to chloroquine (EC50 = 482 nM). Notably, it achieves this without causing toxicity in A-10 vascular smooth muscle cells (IC50 = >10,000 nM). |
Synonyms | R 21345 |
Molecular Weight | 448.98 |
Formula | C27H29ClN2O2 |
CAS No. | 66164-06-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Acetonitrile: slightly soluble
Chloroform: sparingly soluble
You can also refer to dose conversion for different animals. More
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N-didesmethyl Loperamide 66164-06-5 R 21345 inhibitor inhibit