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PPARα/γ agonist 4
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Catalog No. T89021
Compound (S)-7, also known as PPARα/γ agonist 4, is a dual potent agonist for PPARα and PPARγ with EC50 values of 0.061 μM and 1.42 μM, respectively. This compound exhibits oral efficacy and operates through an insulin-independent mechanism, featuring mitochondrial pyruvate carrier inhibition and antidiabetic properties. PPARα/γ agonist 4 holds potential for research in dyslipidemic type 2 diabetes.
PPARα/γ agonist 4
PPARα/γ agonist 4
Copy Product Info😃Good
Catalog No. T89021
Compound (S)-7, also known as PPARα/γ agonist 4, is a dual potent agonist for PPARα and PPARγ with EC50 values of 0.061 μM and 1.42 μM, respectively. This compound exhibits oral efficacy and operates through an insulin-independent mechanism, featuring mitochondrial pyruvate carrier inhibition and antidiabetic properties. PPARα/γ agonist 4 holds potential for research in dyslipidemic type 2 diabetes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Compound (S)-7, also known as PPARα/γ agonist 4, is a dual potent agonist for PPARα and PPARγ with EC50 values of 0.061 μM and 1.42 μM, respectively. This compound exhibits oral efficacy and operates through an insulin-independent mechanism, featuring mitochondrial pyruvate carrier inhibition and antidiabetic properties. PPARα/γ agonist 4 holds potential for research in dyslipidemic type 2 diabetes. |
| Targets&IC50 | PPARβ/δ:1475 nM (EC50), PPARα:3255 nM (EC50) |
| In vitro | PPARα/γ agonist 4 (100 nM, 24 hours) enhances glucose uptake and metabolism in the C2C12 cell line and prevents lipid accumulation in liver or muscle cells by boosting mitochondrial activity associated with fatty acid degradation. |
| In vivo | Compound PPARα/γ agonist 4, administered orally at doses of 25 mg/kg and 50 mg/kg over a 15-day treatment period, exhibits dose-dependent antihyperglycemic effects and significant lipid-lowering properties in a diabetic mouse model. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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