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Anti-IGF1R/CD221 Antibody-PE (1V195)
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Catalog No. TMAY-00383P
Anti-IGF1R/CD221 Antibody-PE (1V195) is a PE-conjugated Rabbit antibody targeting IGF1R/CD221. Anti-IGF1R/CD221 Antibody-PE (1V195) can be used in FCM.
Anti-IGF1R/CD221 Antibody-PE (1V195)
Anti-IGF1R/CD221 Antibody-PE (1V195)
🥰Excellent
Catalog No. TMAY-00383P
Anti-IGF1R/CD221 Antibody-PE (1V195) is a PE-conjugated Rabbit antibody targeting IGF1R/CD221. Anti-IGF1R/CD221 Antibody-PE (1V195) can be used in FCM.
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Product Introduction
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Chemical Properties
| Description | Anti-IGF1R/CD221 Antibody-PE (1V195) is a PE-conjugated Rabbit antibody targeting IGF1R/CD221. Anti-IGF1R/CD221 Antibody-PE (1V195) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 1V195 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of anti-Human IGF1R on HeLa cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human IGF1R / CD221 (rh IGF1R / CD221; TMPY-00834; NP_000866.1; Met1-Asn932) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. The IGF1R signaling pathway is activated in the mammalian nervous system from the early developmental stages. Its major effect on developing neural cells is to promote their growth and survival. This pathway can integrate its action with signaling pathways of growth and morphogenetic factors that induce cell fate specification and selective expansion of specified neural cell subsets. Modulation of cell migration is another possible role that IGF1R activation may play in neurogenesis. In the mature brain, IGF-I binding sites have been found in different regions of the brain, and multiple reports confirmed a strong neuroprotective action of the IGF-IR against different pro-apoptotic insults. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells. IGF1R is frequently overexpressed by tumors and mediates proliferation and apoptosis protection. IGF signaling also influences hypoxia signaling, protease secretion, tumor cell motility, and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, IGF1R is now an attractive anti-cancer treatment target.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/FITC |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human IGF1R / CD221 protein (TMPY-00834) |
| Antigen Species | Human |
| Biology Area | Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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