TLR7/8/9 antagonist 2

Name: TLR7/8/9 antagonist 2
Brand: TargetMol
SKU: T72035
Rating: 4.5 (1 reviews)

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Catalog No. T72035Cas No. 2920729-91-3

TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.

TLR7/8/9 antagonist 2

🥰Excellent

Catalog No. T72035Cas No. 2920729-91-3

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Product Introduction

Bioactivity

Description	TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.
Targets&IC50	HEK/hTLR9:0.052 μM, HEK/hTLR7:0.011 μM, HEK/hTLR8:0.029 μM
In vitro	TLR7/8/9 antagonist 2 exhibited inhibitory activity against HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50 values of 0.011 μM, 0.029 μM, and 0,052 μM, respectively.[1] TLR7/8/9 antagonist 2 showed inhibitory activity against hPBMC/TLR9 with an IC50 value of 420 nM.[1]
In vivo	TLR7/8/9 antagonist 2 has a high in vivo bioavailability.[1]

Chemical Properties

Molecular Weight	405.54
Formula	C₂₃H₃₁N₇
Cas No.	2920729-91-3
Smiles	N=1C=C(C=C(C1C2CCN(C=3C=C(N=C4C3C=NN4C)C)CC2)C)N5CCNCC5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc