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MIK665

Name: MIK665
Brand: TargetMol
SKU: T12629L
Price: 135 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: S-64315) Copy Product Info

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Synonyms: S-64315

Catalog No. T12629L Copy Product Info

Purity: 99.85%

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MIK665 (S-64315) is a small-molecule inhibitor and a myeloid cell leukemia sequence 1 (MCL1) inhibitor (IC50 = 1.81 nM) with high selectivity and cell permeability. Used in experimental research, this compound exhibits antitumor activity in hematologic malignancies such as acute myeloid leukemia.

Cas No. 1799631-75-6

Pack Size	Price	USA Stock	Global Stock
1 mg	$135	In Stock	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$455	In Stock	In Stock
25 mg	$753	In Stock	In Stock
50 mg	$1,060	In Stock	In Stock
100 mg	$1,430	In Stock	In Stock
500 mg	$2,860	-	In Stock
1 mL x 10 mM (in DMSO)	$438	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MIK665 (S-64315) is a small-molecule inhibitor and a myeloid cell leukemia sequence 1 (MCL1) inhibitor (IC50 = 1.81 nM) with high selectivity and cell permeability. Used in experimental research, this compound exhibits antitumor activity in hematologic malignancies such as acute myeloid leukemia.
Targets & IC50	H9 cells:250 nM, leukocytes (intermediate):45 nM, leukocytes (sensitive):5.4 nM, MCL1:1.81 nM, leukocytes (resistant):134.8 nM
In vitro	Methods: In AML cells including U937, MV4-11, MOLM-13, and OCI-AML3, 7-AAD/Annexin V staining, Western blot (PARP, caspase-3), and Median Dose-Effect analysis were performed, with cells treated with 1–10 nM MIK665 combined with 2 μM SKI-606 for 24 h. Results: MIK665 and SKI-606 synergistically induced apoptosis, manifested by increased cleavage of PARP and caspase-3, and formation of γH2AX.[1] Methods: In MDS-L, SKM-1, and primary MDS cells, MTS assay and Caspase-Glo 3/7 detection were used, with 50 nM MIK665 alone or combined with GNA treatment for 24–48 h. Results: MIK665 alone mildly inhibited proliferation and increased caspase 3/7 activity; when combined with GNA, it significantly enhanced anti-proliferative and pro-apoptotic effects, and synergistically upregulated Fas expression.[2]
Synonyms	S-64315
Cell Research	MIK665 suppresses H929 cells (IC50: 250 nM).

Chemical Properties

Molecular Weight	875.41
Formula	C₄₇H₄₄ClFN₆O₆S
Cas No.	1799631-75-6
Smiles	O=C(O)C(OC=1N=CN=C2SC(C3=CC=C(F)C=C3)=C(C=4C=CC(OCCN5CCN(C)CC5)=C(Cl)C4C)C12)CC=6C=CC=CC6OCC7=NC(=NC=C7)C=8C=CC=CC8OC
Relative Density.	1.324 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (285.58 mM), Sonication is recommended.

H2O: Insoluble, insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (5.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1423 mL	5.7116 mL	11.4232 mL	57.1161 mL
5 mM	0.2285 mL	1.1423 mL	2.2846 mL	11.4232 mL
10 mM	0.1142 mL	0.5712 mL	1.1423 mL	5.7116 mL
20 mM	0.0571 mL	0.2856 mL	0.5712 mL	2.8558 mL
50 mM	0.0228 mL	0.1142 mL	0.2285 mL	1.1423 mL
100 mM	0.0114 mL	0.0571 mL	0.1142 mL	0.5712 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.