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MIK665

Name: MIK665
Brand: TargetMol
SKU: T12629L
Price: 135 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12629LCas No. 1799631-75-6

Alias S-64315

MIK665 (S-64315) (S-64315) has an inhibitory effect on myeloid leukemia.

MIK665

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Purity: 99.28%

Catalog No. T12629LAlias S-64315Cas No. 1799631-75-6

MIK665 (S-64315) (S-64315) has an inhibitory effect on myeloid leukemia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$135	In Stock	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$455	In Stock	In Stock
25 mg	$753	In Stock	In Stock
50 mg	$1,060	In Stock	In Stock
100 mg	$1,430	In Stock	In Stock
500 mg	$2,860	-	In Stock
1 mL x 10 mM (in DMSO)	$438	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.28%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	MIK665 (S-64315) (S-64315) has an inhibitory effect on myeloid leukemia.
Targets&IC50	leukocytes (sensitive):5.4 nM, MCL1:1.81 nM, leukocytes (intermediate):45 nM, leukocytes (resistant):134.8 nM, H9 cells:250 nM
In vitro	MIK665 (S-64315) had a synergistic effect when combined with ABT-199. Combined treatment with S64315 (0.156-10 μM) and ABT-199 (625 nM) reduced the cell viability of MB2141, MB3616, MB3961, MB4667, A375 and 1205Lu cells. The IC50 of MIK665 interaction with H929 cells was 250 nM[1].
Cell Research	MIK665 suppresses H929 cells (IC50: 250 nM).
Synonyms	S-64315

Chemical Properties

Molecular Weight	875.41
Formula	C₄₇H₄₄ClFN₆O₆S
Cas No.	1799631-75-6
Smiles	COc1ccccc1-c1nccc(COc2ccccc2C[C@@H](Oc2ncnc3sc(c(-c4ccc(OCCN5CCN(C)CC5)c(Cl)c4C)c23)-c2ccc(F)cc2)C(O)=O)n1
Relative Density.	1.324 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (285.58 mM), Sonication is recommended.

H2O: Insoluble, insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (5.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1423 mL	5.7116 mL	11.4232 mL	57.1161 mL
5 mM	0.2285 mL	1.1423 mL	2.2846 mL	11.4232 mL
10 mM	0.1142 mL	0.5712 mL	1.1423 mL	5.7116 mL
20 mM	0.0571 mL	0.2856 mL	0.5712 mL	2.8558 mL
50 mM	0.0228 mL	0.1142 mL	0.2285 mL	1.1423 mL
100 mM	0.0114 mL	0.0571 mL	0.1142 mL	0.5712 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc