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MIK665

Name: MIK665
Brand: TargetMol
SKU: T12629L
Price: 135 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12629LCas No. 1799631-75-6

Alias S-64315

MIK665 (S-64315) (S-64315) has an inhibitory effect on myeloid leukemia.

MIK665

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Purity: 99.28%

Catalog No. T12629LAlias S-64315Cas No. 1799631-75-6

MIK665 (S-64315) (S-64315) has an inhibitory effect on myeloid leukemia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$135	In Stock	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$455	In Stock	In Stock
25 mg	$753	In Stock	In Stock
50 mg	$1,060	In Stock	In Stock
100 mg	$1,430	In Stock	In Stock
500 mg	$2,860	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$438	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.28%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	MIK665 (S-64315) (S-64315) has an inhibitory effect on myeloid leukemia.
Targets&IC50	leukocytes (sensitive):5.4 nM, MCL1:1.81 nM, leukocytes (resistant):134.8 nM, leukocytes (intermediate):45 nM, H9 cells:250 nM
In vitro	MIK665 (S-64315) had a synergistic effect when combined with ABT-199. Combined treatment with S64315 (0.156-10 μM) and ABT-199 (625 nM) reduced the cell viability of MB2141, MB3616, MB3961, MB4667, A375 and 1205Lu cells. The IC50 of MIK665 interaction with H929 cells was 250 nM[1].
Cell Research	MIK665 suppresses H929 cells (IC50: 250 nM).
Synonyms	S-64315

Chemical Properties

Molecular Weight	875.41
Formula	C₄₇H₄₄ClFN₆O₆S
Cas No.	1799631-75-6
Smiles	COc1ccccc1-c1nccc(COc2ccccc2C[C@@H](Oc2ncnc3sc(c(-c4ccc(OCCN5CCN(C)CC5)c(Cl)c4C)c23)-c2ccc(F)cc2)C(O)=O)n1
Relative Density.	1.324 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (285.58 mM), Sonication is recommended.

H2O: Insoluble, insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (5.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1423 mL	5.7116 mL	11.4232 mL	57.1161 mL
5 mM	0.2285 mL	1.1423 mL	2.2846 mL	11.4232 mL
10 mM	0.1142 mL	0.5712 mL	1.1423 mL	5.7116 mL
20 mM	0.0571 mL	0.2856 mL	0.5712 mL	2.8558 mL
50 mM	0.0228 mL	0.1142 mL	0.2285 mL	1.1423 mL
100 mM	0.0114 mL	0.0571 mL	0.1142 mL	0.5712 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc