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BRD0418

Name: BRD0418
Brand: TargetMol
SKU: T30577
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T30577Cas No. 1565827-99-7

Alias BRD-0418, BRD 0418

BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.

BRD0418

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Purity: 99.57%

Catalog No. T30577Alias BRD-0418, BRD 0418Cas No. 1565827-99-7

BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.

Pack Size	Price	Availability
1 mg	$195	In Stock
5 mg	$447	In Stock
10 mg	$659	In Stock
25 mg	$987	In Stock
50 mg	$1,380	In Stock
1 mL x 10 mM (in DMSO)	$536	In Stock

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Batch Information

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Purity:99.57%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.
In vitro	Treatment of HepG2 cells with BRD0418 for 6 hours resulted on average in 3.5-fold up-regulation of TRIB1 transcript levels, with half-maximal effect achieved at 2.3 μM concentration of the compound[1].
Synonyms	BRD-0418, BRD 0418

Chemical Properties

Molecular Weight	488.57
Formula	C₂₉H₃₂N₂O₅
Cas No.	1565827-99-7
Smiles	C(O)[C@H]1[C@]2([C@](C=3C(O2)=CC=C(N(C)C)C3)(C[C@@H](CC(NCC4=CC=C(OC5=CC=CC=C5)C=C4)=O)O1)[H])[H]
Relative Density.	1.220 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (112.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0468 mL	10.2339 mL	20.4679 mL	102.3395 mL
5 mM	0.4094 mL	2.0468 mL	4.0936 mL	20.4679 mL
10 mM	0.2047 mL	1.0234 mL	2.0468 mL	10.2339 mL
20 mM	0.1023 mL	0.5117 mL	1.0234 mL	5.1170 mL
50 mM	0.0409 mL	0.2047 mL	0.4094 mL	2.0468 mL
100 mM	0.0205 mL	0.1023 mL	0.2047 mL	1.0234 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc