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NSC 617145

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Catalog No. T9168Cas No. 203115-63-3
Alias NSC-617145, NSC617145

NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.

NSC 617145

NSC 617145

😃Good
Catalog No. T9168Alias NSC-617145, NSC617145Cas No. 203115-63-3
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$31BackorderBackorder
2 mg$44BackorderBackorder
5 mg$70BackorderBackorder
10 mg$97BackorderBackorder
25 mg$176BackorderBackorder
50 mg$253BackorderBackorder
100 mg$397BackorderBackorder
500 mg$936BackorderBackorder
1 mL x 10 mM (in DMSO)$77-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.
In vitro
NSC 617145 inhibits growth of HeLa cells via formation of DNA double strand breaks (DSBs) and induction of apoptosis in a WRN helicase-dependent manner. NSC 617145 also acts synergistically with mitomycin C to inhibit growth as well as induce DSBs and chromosomal abnormalities in Fanconia-anemia deficient (FA-D2-/-) cells.
SynonymsNSC-617145, NSC617145
Chemical Properties
Molecular Weight400.04
FormulaC13H10Cl4N2O4
Cas No.203115-63-3
SmilesCC(C)(CN1C(=O)C(Cl)=C(Cl)C1=O)CN1C(=O)C(Cl)=C(Cl)C1=O
Relative Density.1.67 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 6 mg/mL (15 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4998 mL12.4988 mL24.9975 mL124.9875 mL
5 mM0.5000 mL2.4998 mL4.9995 mL24.9975 mL
10 mM0.2500 mL1.2499 mL2.4998 mL12.4988 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

WRN helicaseWRNstrandRNASynthesisRNA SynthesisRad51NSC 617145NHEJInhibitorinhibithelicaseDSBdoubleDNASynthesisDNA/RNA SynthesisDNA SynthesischromosomalbreaksATPaseabnormalities
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