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Larsucosterol trimethylamine

Name: Larsucosterol trimethylamine
Brand: TargetMol
SKU: T74147
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T74147

Alias DV-928 trimethylamine, DUR-928 trimethylamine

Larsucosterol trimethylamine (DUR-928 trimethylamine) is a potent liver X receptor (LXR) antagonist that modulates endogenous epigenetics, reduces lipid accumulation in hepatocytes, attenuates lipopolysaccharide (LPS) and TNFα-induced inflammatory responses in macrophages, and alleviates LPS- and acetaminophen (ATMP)-induced multi-organ damage.

Larsucosterol trimethylamine

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Purity: 97.0%

Catalog No. T74147Alias DV-928 trimethylamine, DUR-928 trimethylamine

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.0%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Larsucosterol trimethylamine (DUR-928 trimethylamine) is a potent liver X receptor (LXR) antagonist that modulates endogenous epigenetics, reduces lipid accumulation in hepatocytes, attenuates lipopolysaccharide (LPS) and TNFα-induced inflammatory responses in macrophages, and alleviates LPS- and acetaminophen (ATMP)-induced multi-organ damage.
In vitro	In a model of HG-induced MASLD in humanhepatocytes, Larsucosterol exhibits a specific inhibition of DNMTs. This results in the conversion of 5mCpG to CpG in the promoter regions of 1,074 genes within hepatocytes, leading to the upregulation of genes associated with key sig-naling pathways such as MAPK-ERK, calcium-AMPK, andtype II diabetes mellitus pathways. [1]
In vivo	In a mouse hepatectomy model, larsucosterol upregulates the expression of genes associated with cell replication, including Wt1 (Wilms’ tumor 1),PCNA (proliferating cell nuclear antigen), cMyc (myelocyto-matosis oncogene), cyclin A, FoxM1b (Forkhead Box M1b),and CDC25b (M-phase inducer phosphatase 2), whereas con-currently downregulating the expression of cell cycle arrestgene Chek2 (checkpoint kinase 2) and the apoptotic geneApaf1 (apoptotic peptidase activating factor 1). [1]
Synonyms	DV-928 trimethylamine, DUR-928 trimethylamine

Chemical Properties

Molecular Weight	541.83
Formula	C₃₀H₅₅NO₅S
Smiles	C[C@@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]3[C@H]2CC=C4[C@]3(C)CC[C@H](OS(=O)(O)=O)C4)CCCC(C)(O)C.CN(C)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (36.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8456 mL	9.2280 mL	18.4560 mL	92.2799 mL
5 mM	0.3691 mL	1.8456 mL	3.6912 mL	18.4560 mL
10 mM	0.1846 mL	0.9228 mL	1.8456 mL	9.2280 mL
20 mM	0.0923 mL	0.4614 mL	0.9228 mL	4.6140 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc