Shopping Cart

Your shopping cart is currently empty

Foropafant

Name: Foropafant
Brand: TargetMol
SKU: T15338
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T15338Cas No. 136468-36-5

Alias SR27417

Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM). Foropafant potently inhibits the PAF-induced aggregation of rabbit and human platelets.

Foropafant

Copy Product Info

🥰Excellent

Purity: 99.67%

Catalog No. T15338Alias SR27417Cas No. 136468-36-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$81	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$320	In Stock	In Stock
50 mg	$461	In Stock	In Stock
100 mg	$648	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.67%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Foropafant AI Summary

Foropafant exhibits antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 µM after 48 hours. The inhibition rates were -2.37% and -0.06%, respectively. Additionally, Foropafant shows 7.093% inhibition of SARS-CoV-2 3CL-Pro protease at a 20 µM concentration, indicating potential bioactivity in blocking a crucial enzyme for viral replication. Moreover, the compound displays mixed bioactivities in the enzymatic assay of human HDAC6, with 1.94% inhibition using a commercial peptide substrate and -8.9% inhibition using a custom peptide substrate. These findings suggest that Foropafant has multifaceted interactions with various viral and human proteins, supporting its potential as an antiviral agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM). Foropafant potently inhibits the PAF-induced aggregation of rabbit and human platelets.
Targets&IC50	PAF:57 pM (Ki)
Synonyms	SR27417

Chemical Properties

Molecular Weight	464.71
Formula	C₂₈H₄₀N₄S
Cas No.	136468-36-5
Smiles	CC(C)c1cc(C(C)C)c(-c2csc(n2)N(CCN(C)C)Cc2cccnc2)c(c1)C(C)C
Relative Density.	1.065 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (107.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1519 mL	10.7594 mL	21.5188 mL	107.5940 mL
5 mM	0.4304 mL	2.1519 mL	4.3038 mL	21.5188 mL
10 mM	0.2152 mL	1.0759 mL	2.1519 mL	10.7594 mL
20 mM	0.1076 mL	0.5380 mL	1.0759 mL	5.3797 mL
50 mM	0.0430 mL	0.2152 mL	0.4304 mL	2.1519 mL
100 mM	0.0215 mL	0.1076 mL	0.2152 mL	1.0759 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc