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MNK8 (Alias: 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione)

Name: MNK8
Brand: TargetMol
SKU: T9945
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T9945 Copy Product Info

Purity: 99.74%

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MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1].

MNK8

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Catalog No. T9945

Alias 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione

Cas No. 2055078-49-2

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Pack Size	Price	USA Stock	Global Stock
5 mg	$35	-	In Stock
10 mg	$56	-	In Stock
25 mg	$103	-	In Stock
50 mg	$142	-	In Stock
100 mg	$213	-	In Stock
1 mL x 10 mM (in DMSO)	$34	-	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.74%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1].
In vitro	MNK8, at a concentration of 50 μM over a period of 0 to 48 hours, resulted in a time-dependent increase in Sub-G1 cells and concurrently led to a reduction in the levels of antiapoptotic proteins, namely Bcl-2, survivin, and cyclin D1 [1].
Synonyms	3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione

Chemical Properties

Molecular Weight	252.27
Formula	C₁₅H₁₂N₂O₂
Cas No.	2055078-49-2
Smiles	O=C1C=C(C=2C3=C(C=CC2)C=CC=C3)NC(=O)N1C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (218.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9640 mL	19.8200 mL	39.6401 mL	198.2003 mL
5 mM	0.7928 mL	3.9640 mL	7.9280 mL	39.6401 mL
10 mM	0.3964 mL	1.9820 mL	3.9640 mL	19.8200 mL
20 mM	0.1982 mL	0.9910 mL	1.9820 mL	9.9100 mL
50 mM	0.0793 mL	0.3964 mL	0.7928 mL	3.9640 mL
100 mM	0.0396 mL	0.1982 mL	0.3964 mL	1.9820 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc