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Imatinib impurities3

Name: Imatinib impurities3
Brand: TargetMol
SKU: T67847
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67847Cas No. 404844-11-7

Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.

Imatinib impurities3

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Purity: 98.63%

Catalog No. T67847Cas No. 404844-11-7

Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$36	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$94	In Stock	In Stock
100 mg	$137	-	In Stock
200 mg	$197	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.63%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Imatinib impurities3 AI Summary

Imatinib impurities3 exhibits bioactivity as an inhibitor of human wild type ABL1, KIT, and PDGFRalpha. It shows an IC50 of 6950 nM for ABL1, 245 nM for KIT, and 139 nM for PDGFRalpha, as assessed by [gamma33P]ATP incorporation into specific substrates after 60 minutes via microplate scintillation counting..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.
Targets&IC50	PDGFR:1.39 μM, c-Kit (WT):0.245 μM, Abl-1 (WT):6.95μM

Chemical Properties

Molecular Weight	429.9
Formula	C₂₄H₂₀ClN₅O
Cas No.	404844-11-7
Smiles	Cc1ccc(NC(=O)c2ccc(CCl)cc2)cc1Nc1nccc(n1)-c1cccnc1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (127.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3261 mL	11.6306 mL	23.2612 mL	116.3061 mL
5 mM	0.4652 mL	2.3261 mL	4.6522 mL	23.2612 mL
10 mM	0.2326 mL	1.1631 mL	2.3261 mL	11.6306 mL
20 mM	0.1163 mL	0.5815 mL	1.1631 mL	5.8153 mL
50 mM	0.0465 mL	0.2326 mL	0.4652 mL	2.3261 mL
100 mM	0.0233 mL	0.1163 mL	0.2326 mL	1.1631 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc