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LY 303511 hydrochloride

🥰Excellent
Catalog No. T4423Cas No. 2070014-90-1
Alias LY303511 hydrochloride

LY 303511 hydrochloride is a potent mTOR inhibitor

LY 303511 hydrochloride
Other Forms of LY 303511 hydrochloride:

LY 303511 hydrochloride

🥰Excellent
Purity: 98.47%
Catalog No. T4423Alias LY303511 hydrochlorideCas No. 2070014-90-1
LY 303511 hydrochloride is a potent mTOR inhibitor
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$33In StockIn Stock
5 mg$76In StockIn Stock
10 mg$128In StockIn Stock
25 mg$263In StockIn Stock
50 mg$493In StockIn Stock
100 mg$718In StockIn Stock
1 mL x 10 mM (in DMSO)$84In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.47%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
LY 303511 hydrochloride is a potent mTOR inhibitor
Targets&IC50
mTOR:
In vitro
LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. LY303511 acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms.
SynonymsLY303511 hydrochloride
Chemical Properties
Molecular Weight342.82
FormulaC19H19ClN2O2
Cas No.2070014-90-1
SmilesCl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (145.85 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.83 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9170 mL14.5849 mL29.1698 mL145.8491 mL
5 mM0.5834 mL2.9170 mL5.8340 mL29.1698 mL
10 mM0.2917 mL1.4585 mL2.9170 mL14.5849 mL
20 mM0.1458 mL0.7292 mL1.4585 mL7.2925 mL
50 mM0.0583 mL0.2917 mL0.5834 mL2.9170 mL
100 mM0.0292 mL0.1458 mL0.2917 mL1.4585 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tumor Necrosis Factor ReceptorTNFRTNF ReceptorPotassiumChannelPotassium ChannelmTORLY-303511 HydrochlorideLY303511 HydrochlorideLY-303511LY303511LY 303511 HydrochlorideLY 303511 hydrochlorideLY 303511KcsAInhibitorinhibit
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