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alphaSYN-IN-NAB2

Name: alphaSYN-IN-NAB2
Brand: TargetMol
SKU: T23709
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23709Cas No. 1504588-00-4

Alias NAB2, alphaSYN-IN-NAB2, alphaSYNINNAB2, alphaSYN inhibitor-NAB2, alphaSYN inhibitor NAB2

alphaSYN-IN-NAB2, a neuron-protective agent, is a protein encoded by the NAB2 gene. NAB2 effectively and selectively protects a variety of cells from alpha-SYN toxicity. NAB2 promotes endosomal transport dependent on E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a viable molecular node in alpha-SYN biology that corrects multiple aspects of its underlying pathology, including dysfunctional endosomes and endoplasmic reticulum to Golgi vesicles transport. NAB2 is involved in cellular processes such as cell differentiation, apoptosis and stress response, and can be used to study cancer, neurodevelopment and neuronal activity.

alphaSYN-IN-NAB2

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Purity: 98.49%

Catalog No. T23709Alias NAB2, alphaSYN-IN-NAB2, alphaSYNINNAB2, alphaSYN inhibitor-NAB2, alphaSYN inhibitor NAB2Cas No. 1504588-00-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	In Stock	In Stock
5 mg	$95	In Stock	In Stock
10 mg	$157	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$488	In Stock	In Stock
100 mg	$733	In Stock	In Stock
500 mg	$1,490	-	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:98.49%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Synonyms

NAB2, alphaSYN-IN-NAB2, alphaSYNINNAB2, alphaSYN inhibitor-NAB2, alphaSYN inhibitor NAB2

Chemical Properties

Molecular Weight	389.88
Formula	C₂₃H₂₀ClN₃O
Cas No.	1504588-00-4
Smiles	CC1=C(N2C=3C(=CC(C(NCC4=C(Cl)C=CC=C4)=O)=CC3)N=C2)C=C(C)C=C1
Relative Density.	1.24 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (128.24 mM), Sonication is recommended.

Ethanol: 35.1 mg/mL (90.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5649 mL	12.8245 mL	25.6489 mL	128.2446 mL
5 mM	0.5130 mL	2.5649 mL	5.1298 mL	25.6489 mL
10 mM	0.2565 mL	1.2824 mL	2.5649 mL	12.8245 mL
20 mM	0.1282 mL	0.6412 mL	1.2824 mL	6.4122 mL
50 mM	0.0513 mL	0.2565 mL	0.5130 mL	2.5649 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0256 mL	0.1282 mL	0.2565 mL	1.2824 mL

Calculator

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Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc