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alphaSYN-IN-NAB2

🥰Excellent
Catalog No. T23709Cas No. 1504588-00-4
Alias NAB2, alphaSYN-IN-NAB2, alphaSYNINNAB2, alphaSYN inhibitor-NAB2, alphaSYN inhibitor NAB2

alphaSYN-IN-NAB2, a neuron-protective agent, is a protein encoded by the NAB2 gene. NAB2 effectively and selectively protects a variety of cells from alpha-SYN toxicity. NAB2 promotes endosomal transport dependent on E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a viable molecular node in alpha-SYN biology that corrects multiple aspects of its underlying pathology, including dysfunctional endosomes and endoplasmic reticulum to Golgi vesicles transport. NAB2 is involved in cellular processes such as cell differentiation, apoptosis and stress response, and can be used to study cancer, neurodevelopment and neuronal activity.

alphaSYN-IN-NAB2

alphaSYN-IN-NAB2

🥰Excellent
Purity: 98.49%
Catalog No. T23709Alias NAB2, alphaSYN-IN-NAB2, alphaSYNINNAB2, alphaSYN inhibitor-NAB2, alphaSYN inhibitor NAB2Cas No. 1504588-00-4
alphaSYN-IN-NAB2, a neuron-protective agent, is a protein encoded by the NAB2 gene. NAB2 effectively and selectively protects a variety of cells from alpha-SYN toxicity. NAB2 promotes endosomal transport dependent on E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a viable molecular node in alpha-SYN biology that corrects multiple aspects of its underlying pathology, including dysfunctional endosomes and endoplasmic reticulum to Golgi vesicles transport. NAB2 is involved in cellular processes such as cell differentiation, apoptosis and stress response, and can be used to study cancer, neurodevelopment and neuronal activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$46In StockIn Stock
5 mg$95In StockIn Stock
10 mg$157In StockIn Stock
25 mg$297In StockIn Stock
50 mg$488In StockIn Stock
100 mg$733In StockIn Stock
500 mg$1,490-In Stock
1 mL x 10 mM (in DMSO)$81In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:98.49%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
alphaSYN-IN-NAB2, a neuron-protective agent, is a protein encoded by the NAB2 gene. NAB2 effectively and selectively protects a variety of cells from alpha-SYN toxicity. NAB2 promotes endosomal transport dependent on E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a viable molecular node in alpha-SYN biology that corrects multiple aspects of its underlying pathology, including dysfunctional endosomes and endoplasmic reticulum to Golgi vesicles transport. NAB2 is involved in cellular processes such as cell differentiation, apoptosis and stress response, and can be used to study cancer, neurodevelopment and neuronal activity.
SynonymsNAB2, alphaSYN-IN-NAB2, alphaSYNINNAB2, alphaSYN inhibitor-NAB2, alphaSYN inhibitor NAB2
Chemical Properties
Molecular Weight389.88
FormulaC23H20ClN3O
Cas No.1504588-00-4
SmilesCC1=C(N2C=3C(=CC(C(NCC4=C(Cl)C=CC=C4)=O)=CC3)N=C2)C=C(C)C=C1
Relative Density.1.24 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (128.24 mM), Sonication is recommended.
Ethanol: 35.1 mg/mL (90.03 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.13 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.5649 mL12.8245 mL25.6489 mL128.2446 mL
5 mM0.5130 mL2.5649 mL5.1298 mL25.6489 mL
10 mM0.2565 mL1.2824 mL2.5649 mL12.8245 mL
20 mM0.1282 mL0.6412 mL1.2824 mL6.4122 mL
50 mM0.0513 mL0.2565 mL0.5130 mL2.5649 mL
DMSO
1mg5mg10mg50mg
100 mM0.0256 mL0.1282 mL0.2565 mL1.2824 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

α-synucleinNAB-2NAB 2
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