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Chloropyramine hydrochloride

Name: Chloropyramine hydrochloride
Brand: TargetMol
SKU: T0263
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0263Cas No. 6170-42-9

Alias Nilfan, Halopyramine hydrochloride, Alergosan

Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.

Chloropyramine hydrochloride

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Purity: 99.83%

Catalog No. T0263Alias Nilfan, Halopyramine hydrochloride, AlergosanCas No. 6170-42-9

Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$33	In Stock	In Stock
50 mg	$47	In Stock	In Stock
100 mg	$68	In Stock	In Stock
200 mg	$97	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Chloropyramine hydrochloride AI Summary

Chloropyramine hydrochloride exhibits notable cytotoxicity against a variety of human cancer cell lines, including BT474, MDA-MB-231, T47D, MIAPaCa2, PANC1, C8161, HT-29, COLO205, Saos2, A375, and MCF7. It induces apoptosis in BT474, MCF7, and MCF7 cells expressing VEGFR3, and diminishes the colocalization of FAK-paxillin and FAK-VEGFR3 complexes in these cell types. In xenograft mouse models, it shows significant antitumor activity, reducing tumor growth in BT474 and MCF7 cells expressing VEGFR3. The compound has also demonstrated various bioactivities across multiple targets, including inhibiting Human Jumonji Domain Containing 2E (JMJD2E) with a potency of 35481.3 nM, Aldehyde Dehydrogenase 1 (ALDH1A1) at 11220.2 nM, and Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) at 5011.9 nM. It also inhibits the vitamin D receptor (VDR) at 50118.7 nM and shows inhibitor activity against HP1-beta Chromodomain interactions, Lassa Virus, Marburg Virus, Hepatitis C Virus (HCV), GLP-1 Receptor Inverse Agonists, human tyrosyl-DNA phosphodiesterase 1 (TDP1), and the SARS-CoV-2 3CL-Pro protease. Additionally, it induces growth in a Temperature Sensitive Mutant Burl-1, synthetic lethality in tumor cells producing 2HG, and DNA re-replication in SW480 colon adenocarcinoma cells. Binding affinity to the biotinylated human FAK FAT domain is confirmed with a dissociation constant (Kd) value of 570.0 nM. Chloropyramine hydrochloride shows antiviral activities against SARS-CoV-2, including inhibition of cell viability in Vero E6 and Caco-2 cells infected with the virus, and reduces SARS-CoV-2 induced cytotoxicity in these cells. It achieves a 13.36% inhibition of the SARS-CoV-2 3CL-Pro protease at a concentration of 20µM. However, its effectiveness in some antiviral assays, such as inhibiting SARS CoV-2 induced cytotoxicity in Vero-6 cells, is relatively lower when compared to controls..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist.
Synonyms	Nilfan, Halopyramine hydrochloride, Alergosan

Chemical Properties

Molecular Weight	326.26
Formula	C₁₆H₂₀ClN₃·HCl
Cas No.	6170-42-9
Smiles	Cl.CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 3.59 mg/mL (11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0650 mL	15.3252 mL	30.6504 mL	153.2520 mL
5 mM	0.6130 mL	3.0650 mL	6.1301 mL	30.6504 mL
10 mM	0.3065 mL	1.5325 mL	3.0650 mL	15.3252 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc