Anti-Mouse CD28 Antibody (D665) is a mouse-derived agonistic antibody targeting CD28 that can effectively induce T cell activation and has broad research value in fields such as neurological diseases, inflammation, immunology, and oncology. It can be applied to studies on the mechanisms and interventions of Parkinson's disease (PD), arthritis, and graft-versus-host disease (GVHD).

Anti-Mouse CD28 Antibody (D665) (200 μg, intraperitoneal injection on day 7) alleviated motor dysfunction, reduced dopaminergic neuronal apoptosis in the substantia nigra, and suppressed inflammatory responses in a mouse model of Parkinson’s disease (PD) induced by hαSyn [1].
Anti-Mouse CD28 Antibody (D665) (100 μg, intraperitoneal injection on day 7) reduced the severity of arthritis in a mouse model induced by glucose-6-phosphate isomerase (G6PI) [2].
Anti-Mouse CD28 Antibody (D665) (250 μg, intraperitoneal injection 3 days before isolation of splenic CD4+ cells) prevented graft-versus-host disease in BALB/c mice transplanted with CD4+ cells from C57BL/6 mice [3].
Anti-Mouse CD28 Antibody (D665) (250 μg, intraperitoneal injection 3 days before isolation of T cells from total splenocytes) prolonged the survival of mice with T cell-transferred BCL lymphoma [3].
Anti-Mouse CD28 Antibody (D665) (50 μg/mouse, intraperitoneal injection 3 days before tMCAO) increased the proportion of regulatory T (Treg) cells and exacerbated thrombotic inflammation and ischemic neurodegeneration in a mouse model of transient middle cerebral artery occlusion (tMCAO) [4].

D665

Mouse

Monoclonal

Unconjugated