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Disitertide

Name: Disitertide
Brand: TargetMol
SKU: T11052
Rating: 4.5 (1 reviews)

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Catalog No. T11052Cas No. 272105-42-7

Alias P144

Disitertide (P144) is an inhibitor of TGF-β1.

Disitertide

😃Good

Catalog No. T11052Alias P144Cas No. 272105-42-7

Disitertide (P144) is an inhibitor of TGF-β1.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$642	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Disitertide (P144) is an inhibitor of TGF-β1.
In vitro	Aurora B inhibitor 1 also inhibits JAK3 and JAK2 with Kis of <0.25 μM and <0.10 μM, respectively[1].
In vivo	In the rat model of long-term exposure to CCl4, low-dose Disitertide (P144) treatment can significantly inhibit HSC activation and significantly reduce liver fibrosis.
Synonyms	P144

Chemical Properties

Molecular Weight	1580.84
Formula	C₆₈H₁₀₉N₁₇O₂₂S₂
Cas No.	272105-42-7
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O
Relative Density.	1.327g/cm3
Sequence Short	TSLDASIIWAMMQN

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (126.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6326 mL	3.1629 mL	6.3258 mL	31.6288 mL
5 mM	0.1265 mL	0.6326 mL	1.2652 mL	6.3258 mL
10 mM	0.0633 mL	0.3163 mL	0.6326 mL	3.1629 mL
20 mM	0.0316 mL	0.1581 mL	0.3163 mL	1.5814 mL
50 mM	0.0127 mL	0.0633 mL	0.1265 mL	0.6326 mL
100 mM	0.0063 mL	0.0316 mL	0.0633 mL	0.3163 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc