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BMS-817399

Name: BMS-817399
Brand: TargetMol
SKU: T26861
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26861Cas No. 1202400-18-7

Alias BMS817399

BMS-817399 is an orally active antagonist of CCR1 with IC50s of binding affinity and chemotaxis inhibition potencies and can be used in studies about rheumatoid arthritis.

BMS-817399

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Purity: 99.7%

Catalog No. T26861Alias BMS817399Cas No. 1202400-18-7

BMS-817399 is an orally active antagonist of CCR1 with IC50s of binding affinity and chemotaxis inhibition potencies and can be used in studies about rheumatoid arthritis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	In Stock	In Stock
5 mg	$213	In Stock	In Stock
10 mg	$323	In Stock	In Stock
25 mg	$513	In Stock	In Stock
50 mg	$690	In Stock	In Stock
100 mg	$930	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$238	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.7%

ee:100%

Appearance:Solid

Color:White

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COA CSFC ORP HNMR LCMS

Product Introduction

BMS-817399 AI Summary

BMS-817399 shows potent antagonist activity at the CCR1 receptor, inhibiting chemotaxis induced by various ligands such as MIP-1alpha, RANTES, MCP3, HCC1, LKN1, HCC4, and MPIF1 in human THP1 cells with IC50 values ranging from 3.2 to 16.2 nM. It also effectively displaces [125I]MIP-1alpha from CCR1 in THP1 cells and human PBMC, with IC50 values ranging from 1.0 to 4.2 nM. Additionally, the compound inhibits MIP-1alpha-induced calcium flux with an IC50 of 3.0 nM and has demonstrated low metabolic stability in rodent liver microsomes but higher stability in human liver microsomes. It exhibits good bioavailability in dogs and mice, moderate bioavailability in rats and cynomolgus monkeys, and an unbound fraction of 0.19 in human serum..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BMS-817399 is an orally active antagonist of CCR1 with IC50s of binding affinity and chemotaxis inhibition potencies and can be used in studies about rheumatoid arthritis.
Targets&IC50	CCR1:1 nM (IC50)
Synonyms	BMS817399

Chemical Properties

Molecular Weight	454
Formula	C₂₃H₃₆ClN₃O₄
Cas No.	1202400-18-7
Smiles	O[C@]1(C(C)(C)CN(C([C@H](NC(NCC(C)(C)O)=O)[C@@H](C)C)=O)CC1)C2=CC=C(Cl)C=C2
Relative Density.	1.182 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (121.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2026 mL	11.0132 mL	22.0264 mL	110.1322 mL
5 mM	0.4405 mL	2.2026 mL	4.4053 mL	22.0264 mL
10 mM	0.2203 mL	1.1013 mL	2.2026 mL	11.0132 mL
20 mM	0.1101 mL	0.5507 mL	1.1013 mL	5.5066 mL
50 mM	0.0441 mL	0.2203 mL	0.4405 mL	2.2026 mL
100 mM	0.0220 mL	0.1101 mL	0.2203 mL	1.1013 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc