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(+)-KCC2 blocker 1

Name: (+)-KCC2 blocker 1
Brand: TargetMol
SKU: T12504
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12504Cas No. 1228439-71-1

(+)-KCC2 blocker 1 is a selective inhibitor of KCC2 with an IC50 of 0.4 μM.

(+)-KCC2 blocker 1

🥰Excellent

Purity: 99.88%

Catalog No. T12504Cas No. 1228439-71-1

(+)-KCC2 blocker 1 is a selective inhibitor of KCC2 with an IC50 of 0.4 μM.

Pack Size	Price	Availability
1 mg	$117	In Stock
2 mg	$175	In Stock
5 mg	$268	In Stock
10 mg	$394	In Stock
25 mg	$592	In Stock
50 mg	$828	In Stock
100 mg	$1,130	In Stock
500 mg	$2,260	In Stock
1 mL x 10 mM (in DMSO)	$298	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.88%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	(+)-KCC2 blocker 1 is a selective inhibitor of KCC2 with an IC50 of 0.4 μM.
Targets&IC50	KCC2:0.4 μM
In vitro	(+)-KCC2 blocker 1 is an enantiomer of KCC2 blocker 1 and possesses a 100-fold difference in potency compared to (-)-KCC2 blocker 1[1].

Chemical Properties

Molecular Weight	415.5
Formula	C₂₂H₂₅NO₅S
Cas No.	1228439-71-1
Smiles	C(C1(C(OCC2=CC=CC=C2)=O)N(C(C)=O)CCC1)C3=CC=C(S(C)(=O)=O)C=C3
Relative Density.	1.267 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (120.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4067 mL	12.0337 mL	24.0674 mL	120.3369 mL
5 mM	0.4813 mL	2.4067 mL	4.8135 mL	24.0674 mL
10 mM	0.2407 mL	1.2034 mL	2.4067 mL	12.0337 mL
20 mM	0.1203 mL	0.6017 mL	1.2034 mL	6.0168 mL
50 mM	0.0481 mL	0.2407 mL	0.4813 mL	2.4067 mL
100 mM	0.0241 mL	0.1203 mL	0.2407 mL	1.2034 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc