Shopping Cart

Your shopping cart is currently empty

UniPR129

Name: UniPR129
Brand: TargetMol
SKU: T26310
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: UniPR-129, UniPR 129) Copy Product Info

🥰Excellent

Synonyms: UniPR-129, UniPR 129

Catalog No. T26310 Copy Product Info

🥰Excellent

UniPR129 is a highly selective, cell-permeable, competitive Eph/ephrin antagonist belonging to the class of L-tryptophan derivatives of lithocholic acid. UniPR129 inhibits the interaction between EphA2 and ephrin-A1 with an IC₅₀ of 945 nM and a Ki of 345 nM. UniPR129 inhibits angiogenesis in HUVEC cells with an IC₅₀ of 5.2 μM. UniPR129 exhibits antitumor and neuroprotective effects and can be used in research on cancer and neurological diseases.

Cas No. 1639159-47-9

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$93	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	UniPR129 is a highly selective, cell-permeable, competitive Eph/ephrin antagonist belonging to the class of L-tryptophan derivatives of lithocholic acid. UniPR129 inhibits the interaction between EphA2 and ephrin-A1 with an IC₅₀ of 945 nM and a Ki of 345 nM. UniPR129 inhibits angiogenesis in HUVEC cells with an IC₅₀ of 5.2 μM. UniPR129 exhibits antitumor and neuroprotective effects and can be used in research on cancer and neurological diseases.
Targets & IC50	EphA8:0.84 μM, EphB4:2.60 μM, EphA2:1.12 μM, EphB5:3.01 μM, EphB1:2.75 μM, EphA7:1.24 μM, EphA4:1.58 μM, EphA5:1.57 μM, EphA3:1.43 μM, EphA6:1.53 μM, EphB3:3.74 μM, EphA1:1.39 μM, EphB2:2.96 μM
In vitro	Methods: Human umbilical vein endothelial cells (HUVECs) were incubated with 0–50 μM UniPR129 for 1 hour, then seeded onto Matrigel; 15 hours later, the formed multi-lumen structures were counted. Results: UniPR129 effectively inhibited in vitro angiogenesis, with an IC₅₀ of 6.2 μM.[1]
In vivo	Methods: To investigate the antitumor effects of UniPR129, APC min/J mice (C57BL6/J background, male, 5 weeks old) were selected and administered UniPR129 (30 mg/kg) orally starting at 5 weeks of age for 8 weeks. Results: Treatment with UniPR129 reduced the number of ileal adenomas by 42% and the total number of intestinal adenomas by 29%; adenoma diameter was significantly reduced, and no large or giant adenomas were observed.[2]
Synonyms	UniPR-129, UniPR 129

Chemical Properties

Molecular Weight	576.81
Formula	C₃₆H₅₂N₂O₄
Cas No.	1639159-47-9
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(N[C@@H](CC=5C=6C(NC5)=CC=CC6)CC(O)=O)=O)C)[H])[H]
Relative Density.	1.162 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1?mg/mL?(insoluble)

DMSO: 26.66 mg/mL (46.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7337 mL	8.6684 mL	17.3367 mL	86.6837 mL
5 mM	0.3467 mL	1.7337 mL	3.4673 mL	17.3367 mL
10 mM	0.1734 mL	0.8668 mL	1.7337 mL	8.6684 mL
20 mM	0.0867 mL	0.4334 mL	0.8668 mL	4.3342 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.