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(1S,2R)-2-PCCA

Catalog No. T13423L

Synonyms: (1S,2R)-2-PCCA（Iso-1609563-71-4）

(1S,2R)-2-PCCA is a novel and potent small molecule GPR88 receptor agonist with an EC50 value of 3 nM in the non-cellular system and 603 nM in the cellular system.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

(1S,2R)-2-PCCA, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 465.00
10 mg	In stock	$ 679.00
25 mg	In stock	$ 1,070.00
50 mg	In stock	$ 1,430.00
100 mg	In stock	$ 1,930.00

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Purity: 99.34%

ee: 98.36%

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Description	(1S,2R)-2-PCCA is a novel and potent small molecule GPR88 receptor agonist with an EC50 value of 3 nM in the non-cellular system and 603 nM in the cellular system.
Targets&IC50	GPR88 receptor:3 nM (EC50), Gαi-coupled pathway:56 nM
In vitro	(1R,2R)-2-PCCA (Example 3) is a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay and 603 nM in cell assay[1][2]. In HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct, (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 56 nM[2].

Synonyms	(1S,2R)-2-PCCA（Iso-1609563-71-4）
Molecular Weight	528.56
Formula	C30H39Cl2N3O

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bi, Yingzhi, et al. Modulators of G Protein-Coupled Receptor 88. US 20110251204 A1. 2. Jin C, et al. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432. 3. Jin C, et al. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(1S,2R)-2-PCCA Endocrinology/Hormones GPCR/G Protein GPR 1609563-71-4-isomer 2-PCCA (1S,2R)-2-PCCA（Iso-1609563-71-4） inhibitor inhibit

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