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(1S,2R)-2-PCCA

Name: (1S,2R)-2-PCCA
Brand: TargetMol
SKU: T13423L
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13423L

Alias (1S,2R)-2-PCCA（Iso-1609563-71-4）

(1S,2R)-2-PCCA is a novel and potent small molecule GPR88 receptor agonist with an EC50 value of 3 nM in the non-cellular system and 603 nM in the cellular system.

(1S,2R)-2-PCCA

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Purity: 99.91%

Catalog No. T13423LAlias (1S,2R)-2-PCCA（Iso-1609563-71-4）

(1S,2R)-2-PCCA is a novel and potent small molecule GPR88 receptor agonist with an EC50 value of 3 nM in the non-cellular system and 603 nM in the cellular system.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$82	-	In Stock
5 mg	$195	-	In Stock
10 mg	$285	-	In Stock
25 mg	$449	-	In Stock
50 mg	$659	-	In Stock
100 mg	$939	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

ee:98.36%

Appearance:Solid

Color:Blue

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COA CSFC HNMR IC ORP LCMS

Product Introduction

Bioactivity

Description	(1S,2R)-2-PCCA is a novel and potent small molecule GPR88 receptor agonist with an EC50 value of 3 nM in the non-cellular system and 603 nM in the cellular system.
Targets&IC50	GPR88 receptor:3 nM (EC50), Gαi-coupled pathway:56 nM
In vitro	(1R,2R)-2-PCCA (Example 3) is a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay and 603 nM in cell assay[1][2]. In HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct, (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 56 nM[2].
Synonyms	(1S,2R)-2-PCCA（Iso-1609563-71-4）

Chemical Properties

Molecular Weight	528.56
Formula	C₃₀H₃₉Cl₂N₃O
Smiles	CC[C@H](C)[C@H](N)CN(C1=CC=C(C2=CC=C(C=C2)CCC)C=C1)C([C@@H]3[C@H](C4=CC=CC=N4)C3)=O.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (104.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8919 mL	9.4597 mL	18.9193 mL	94.5966 mL
5 mM	0.3784 mL	1.8919 mL	3.7839 mL	18.9193 mL
10 mM	0.1892 mL	0.9460 mL	1.8919 mL	9.4597 mL
20 mM	0.0946 mL	0.4730 mL	0.9460 mL	4.7298 mL
50 mM	0.0378 mL	0.1892 mL	0.3784 mL	1.8919 mL
100 mM	0.0189 mL	0.0946 mL	0.1892 mL	0.9460 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc