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ROS kinases-IN-2

Name: ROS kinases-IN-2
Brand: TargetMol
SKU: T74671
Price: 66 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T74671Cas No. 687576-28-9

ROS kinases-IN-2, with an inhibition rate of 21.53% at 10 μM, is a potent ROS kinase inhibitor with potential anticancer activity and applications in studying abnormal cell growth.

ROS kinases-IN-2

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Purity: 99.54%

Catalog No. T74671Cas No. 687576-28-9

ROS kinases-IN-2, with an inhibition rate of 21.53% at 10 μM, is a potent ROS kinase inhibitor with potential anticancer activity and applications in studying abnormal cell growth.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$66	-	In Stock
5 mg	$159	-	In Stock
10 mg	$223	-	In Stock
25 mg	$333	-	In Stock
50 mg	$457	-	In Stock
100 mg	$622	-	In Stock
200 mg	$833	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.54%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

ROS kinases-IN-2 AI Summary

ROS kinases-IN-2 exhibits a diverse range of bioactivities. It inhibits several enzymes including human Jumonji Domain Containing 2E (JMJD2E), Aldehyde Dehydrogenase 1 (ALDH1A1), mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), Polymerase Iota, Secretory Acid Sphingomyelinase (S-ASM), and human tyrosyl-DNA phosphodiesterase 1 (TDP1) both in the absence and presence of CPT. It also demonstrates efficacy in modulating lipid storage in Drosophila S3 cells, inhibiting ELG1-dependent DNA repair in human embryonic kidney cells, acting as a delayed death inhibitor of the malarial parasite plastid, and blocking binding or entry into cells for Lassa Virus and Marburg Virus. Furthermore, it induces DNA re-replication in normal breast cells, inhibits Hepatitis C Virus (HCV), and ATXN expression. Additionally, it serves as an inverse agonist of the GLP-1 Receptor and activates integrin-mediated alleviation for muscular dystrophy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

ROS kinases-IN-2, with an inhibition rate of 21.53% at 10 μM, is a potent ROS kinase inhibitor with potential anticancer activity and applications in studying abnormal cell growth.

Chemical Properties

Molecular Weight	437.54
Formula	C₂₂H₁₉N₃O₃S₂
Cas No.	687576-28-9
Smiles	O=C(NCCC1=CC=C(C=C1)S(=O)(=O)N)C=2C=C(N=C3C=CC=CC32)C=4SC=CC4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (125.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2855 mL	11.4275 mL	22.8551 mL	114.2753 mL
5 mM	0.4571 mL	2.2855 mL	4.5710 mL	22.8551 mL
10 mM	0.2286 mL	1.1428 mL	2.2855 mL	11.4275 mL
20 mM	0.1143 mL	0.5714 mL	1.1428 mL	5.7138 mL
50 mM	0.0457 mL	0.2286 mL	0.4571 mL	2.2855 mL
100 mM	0.0229 mL	0.1143 mL	0.2286 mL	1.1428 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc