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Cofetuzumab pelidotin
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Catalog No. T9901A-055Cas No. 1869937-48-3
Cofetuzumab pelidotin (PF-06647020) is an antibody-drug conjugate (ADC) targeting PTK7, composed of the humanized anti-PTK7 monoclonal antibody (hu6M024, IgG1) linked to the auristatin-based microtubule inhibitor payload, auristatin-0101 (Aur0101), via a cleavable valine-citrulline (vc)-based linker. This compound exhibits a drug-to-antibody ratio (DAR) of 4 and selectively binds to cell-surface PTK7 with an EC50 of 1153 pM as determined by flow cytometry. Cofetuzumab pelidotin holds promise for the study of solid tumors [1] [2] [3].
Cofetuzumab pelidotin
Cofetuzumab pelidotin
😃Good
Catalog No. T9901A-055Cas No. 1869937-48-3
Cofetuzumab pelidotin (PF-06647020) is an antibody-drug conjugate (ADC) targeting PTK7, composed of the humanized anti-PTK7 monoclonal antibody (hu6M024, IgG1) linked to the auristatin-based microtubule inhibitor payload, auristatin-0101 (Aur0101), via a cleavable valine-citrulline (vc)-based linker. This compound exhibits a drug-to-antibody ratio (DAR) of 4 and selectively binds to cell-surface PTK7 with an EC50 of 1153 pM as determined by flow cytometry. Cofetuzumab pelidotin holds promise for the study of solid tumors [1] [2] [3].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Cofetuzumab pelidotin (PF-06647020) is an antibody-drug conjugate (ADC) targeting PTK7, composed of the humanized anti-PTK7 monoclonal antibody (hu6M024, IgG1) linked to the auristatin-based microtubule inhibitor payload, auristatin-0101 (Aur0101), via a cleavable valine-citrulline (vc)-based linker. This compound exhibits a drug-to-antibody ratio (DAR) of 4 and selectively binds to cell-surface PTK7 with an EC50 of 1153 pM as determined by flow cytometry. Cofetuzumab pelidotin holds promise for the study of solid tumors [1] [2] [3]. |
| In vitro | Cofetuzumab pelidotin (PF-06647020) exhibits cytotoxic effects in vitro against PTK7-expressing cancer cell lines H446, H661, and OVCAR3, with EC50 values of 7.6, 27.5, and 105 ng/mL, respectively[1]. Over a duration of six days, it shows high potency and PTK7-specific cytotoxicity in a range of cancer cell lines (A549, MDA-MB-468, KYSE-150, SKOV-3, PC9, NCI-H1975), with IC50 values ranging from 0 to 1100 nM[2]. However, its stability is relatively poor, with a T1/2 of less than 3 days[2]. |
| In vivo | Cofetuzumab pelidotin (PF-06647020; 3 mg/kg; intraperitoneal injection twice weekly for four cycles) demonstrated significant in vivo antitumor activity in patient-derived xenograft (PDX) models of NSCLC, OVCA, and TNBC [1]. The study utilized NOD scid mice aged 6 to 10 weeks, harboring cells from these cancers [1]. The findings confirm that the specified dosage and administration route effectively suppress these tumor cells. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | ＜ 1.0 EU/mg |
| Target | PTK7 |
| Cas No. | 1869937-48-3 |
| Storage | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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