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OTSSP167
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Catalog No. T1759Cas No. 1431697-89-0
Alias OTS167, MELK inhibitor
OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
OTSSP167
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Purity: 99.47%
Catalog No. T1759Alias OTS167, MELK inhibitorCas No. 1431697-89-0
OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $34 | In Stock | In Stock | |
| 2 mg | $47 | In Stock | In Stock | |
| 5 mg | $80 | In Stock | In Stock | |
| 10 mg | $122 | In Stock | In Stock | |
| 25 mg | $197 | In Stock | In Stock | |
| 50 mg | $297 | In Stock | In Stock | |
| 100 mg | $455 | In Stock | In Stock | |
| 500 mg | $987 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.47%
Color:Yellow
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Product Introduction
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Storage & Solubility Information
| Description | OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. |
| Targets&IC50 | MELK:0.41 nM |
| In vitro | OTSSP167 inhibited the phosphorylation of PSMA1 and DBNL, novel MELK substrates that are essential for stem cell characterization and invasiveness.OTSSP167 inhibited sphere formation in breast cancer cells by inhibiting PSMA1 phosphorylation.OTSSP167 inhibited high levels of MELK expression in A549, T47D, DU4475 and 22Rv1 cancer cells with IC50 of 6.7, 4.3, 2.3 and 6.0 nM, respectively. |
| In vivo | OTSSP167 inhibited the phosphorylation of PSMA1 and DBNL, novel MELK substrates that are essential for stem cell characterization and invasiveness.OTSSP167 inhibited sphere formation in breast cancer cells by inhibiting PSMA1 phosphorylation.OTSSP167 inhibited high levels of MELK expression in A549, T47D, DU4475 and 22Rv1 cancer cells with IC50 of 6.7, 4.3, 2.3 and 6.0 nM, respectively. |
| Kinase Assay | in vitro kinase assay: MELK recombinant protein (0.4 μg) is mixed with 5 μg of each substrate in 20 μL of kinase buffer containing 30 mM Tris-HCl (pH), 10 mM DTT, 40 mM NaF, 10 mM MgCl2, 0.1 mM EGTA with 50 μM cold-ATP and 10 Ci of [γ-32P]ATP for 30 min at 30 °C. The reaction is terminated by addition of SDS sample buffer and boiled for 5 min prior to SDS-PAGE. The gel is dried and autoradiographed with intensifying screens at room temperature. OTSSP167 (final concentration of 10 nM) is dissolved in DMSO and added to kinase buffer before the incubation. |
| Cell Research | Cell Counting Kit-8(Only for Reference) |
| Synonyms | OTS167, MELK inhibitor |
| Molecular Weight | 487.42 |
| Formula | C25H28Cl2N4O2 |
| Cas No. | 1431697-89-0 |
| Smiles | CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O |
| Relative Density. | no data available |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 7.22 mg/mL (14.81 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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