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Aminaftone (Synonyms: Aminaphthone)

Name: Aminaftone
Brand: TargetMol
SKU: T14219
Price: 200 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T14219 Copy Product Info

Purity: 99.39%

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Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and is used to study hypertension and systemic sclerosis.

Aminaftone

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Catalog No. T14219

Synonyms Aminaphthone

Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and is used to study hypertension and systemic sclerosis.

Cas No. 14748-94-8

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Pack Size	Price	USA Stock	Global Stock
1 mg	$200	In Stock	In Stock
5 mg	$560	In Stock	In Stock
10 mg	$1,020	In Stock	In Stock
25 mg	$1,820	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.39%

Appearance:Solid

Color:Yellow

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and is used to study hypertension and systemic sclerosis.
In vitro	In cell cultures, Aminaftone inhibits the production of Endothelin-1 (ET-1) by interfering with the transcription of the pre-pro-endothelin-1 (PPET-1) gene. Concentrations of ET-1 and PPET-1 relative gene expression increase upon incubation with IL-1beta. Aminaftone, when incubated in a concentration-dependent manner, significantly reduces the production of ET-1. A strong direct correlation is observed between ET-1 concentrations and PPET-1 relative gene expression. It is noteworthy that Aminaftone does not influence the activity of endothelin-converting enzyme (ECE)[2].
In vivo	After 5 weeks, rats are randomly assigned to the following experimental groups: Control; Monocrotaline; Aminaftone 30 mg/kg/day; Aminaftone 150 mg/kg/day. In animals treated with Aminaftone at both doses, mortality is significantly lower compared to those treated with Monocrotaline alone. Aminaftone, especially at the highest dose, reduces the plasma concentration of ET-1 and appears to decrease right heart hypertrophy and the wall thickness of the pulmonary arteries. At the end of the experiment, no rats die in the control and Aminaftone 150 groups, while mortality is 38% in the Monocrotaline group and 13% in the Aminaftone 30 group. Overall, rats treated with Aminaftone show a significantly lower mortality compared to rats in the Monocrotaline group (P=0.044)[1].
Synonyms	Aminaphthone

Chemical Properties

Molecular Weight	309.32
Formula	C₁₈H₁₅NO₄
Cas No.	14748-94-8
Smiles	OC=1C2=C(C(O)=C(C)C1OC(=O)C3=CC=C(N)C=C3)C=CC=C2
Relative Density.	1.39g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,The compound is unstable in solution. Please use soon | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (193.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2329 mL	16.1645 mL	32.3290 mL	161.6449 mL
5 mM	0.6466 mL	3.2329 mL	6.4658 mL	32.3290 mL
10 mM	0.3233 mL	1.6164 mL	3.2329 mL	16.1645 mL
20 mM	0.1616 mL	0.8082 mL	1.6164 mL	8.0822 mL
50 mM	0.0647 mL	0.3233 mL	0.6466 mL	3.2329 mL
100 mM	0.0323 mL	0.1616 mL	0.3233 mL	1.6164 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc