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MR837
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Catalog No. T8879Cas No. 1210906-48-1
Alias ZINC30303842, NSD2-PWWP1 antagonist 3f
MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.
MR837
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Purity: 99.85%
Catalog No. T8879Alias ZINC30303842, NSD2-PWWP1 antagonist 3fCas No. 1210906-48-1
MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $34 | In Stock | In Stock | |
| 5 mg | $53 | In Stock | In Stock | |
| 10 mg | $88 | In Stock | In Stock | |
| 25 mg | $148 | In Stock | In Stock | |
| 50 mg | $269 | In Stock | In Stock | |
| 100 mg | $395 | In Stock | In Stock | |
| 200 mg | $557 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $64 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.85%
Appearance:Solid
Color:White
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Product Introduction
MR837 AI Summary
MR837 has bioactivities related to both the NSD2 and NSD3 proteins. It shows notable binding affinity to the NSD2 PWWP1 domain with dissociation constants (Kd) of 7000.0 nM and 3400.0 nM under different conditions. Additionally, it can displace Halo-tagged Histone H3.3 from Nanoluc-tagged NSD2-PWWP1 in human U2OS cells with an IC50 value of 17300.0 nM. Moreover, it exhibits a dissociation constant (Kd) of 91.0 nM when binding to NSD3. The compound also shows binding affinity to the N-terminal His6/Sumo-tagged NSD2 PWWP1 domain (211 to 350 residues) with an IC50 value of 24670.0 nM, as assessed using the HTRF assay method with a specific substrate..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist. |
| Synonyms | ZINC30303842, NSD2-PWWP1 antagonist 3f |
| Molecular Weight | 282.36 |
| Formula | C16H14N2OS |
| Cas No. | 1210906-48-1 |
| Smiles | O=C(N(Cc1cccs1)C1CC1)c1ccc(cc1)C#N |
| Relative Density. | 1.29 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (38.96 mM), Sonication is recommended.  | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.08 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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