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Riboflavin

Name: Riboflavin
Brand: TargetMol
SKU: T0937
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0937Cas No. 83-88-5

Alias Vitamin B2, E101

Riboflavin (Vitamin B2) is a natural product, an endogenous human metabolite, and a micronutrient. Riboflavin is essential for the formation of two major coenzymes, flavin mononucleotide and flavin adenine dinucleotide. Riboflavin is involved in energy metabolism, cellular respiration, and antibody production, as well as normal growth and development.

Riboflavin

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Purity: 99.43%

Catalog No. T0937Alias Vitamin B2, E101Cas No. 83-88-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$33	In Stock	In Stock
2 g	$40	In Stock	In Stock
5 g	$54	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.43%

Appearance:Solid

Color:Yellow to Orange

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COA HPLC HNMR

Product Introduction

Riboflavin AI Summary

Riboflavin exhibits a wide range of bioactivities, including enzyme inhibition, antiviral, cytotoxic, and other biological activities. It shows inhibitory activity against beta-lactamase, chymotrypsin, malate dehydrogenase, SRC2-3 interaction with the androgen receptor, BRCT-Phosphoprotein interaction, RecQ-Like DNA Helicase 1, and various other targets. It specifically inhibits Ebola virus entry and SARS-CoV-2 induced cytotoxicity with moderate potency. The compound also demonstrates binding affinity to chicken riboflavin binding protein and influences growth parameters and disease resistance in Cenchrus americanus cultivar 7042S. Additionally, Riboflavin inhibits OATP1B1 and OATP1B3-mediated uptake of sodium fluorescein. It exhibits photooxidative activity and potentiates apoptosis under blue light irradiation. Despite exhibiting cytotoxicity against human THLE cells, it shows no liver toxicity in humans. The compound's antiviral activity extends to interaction with SARS-CoV-2 3CL-Pro protease. Its complex bioactivity profile suggests potential therapeutic applications and biological significance across various domains..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Riboflavin (Vitamin B2) is a natural product, an endogenous human metabolite, and a micronutrient. Riboflavin is essential for the formation of two major coenzymes, flavin mononucleotide and flavin adenine dinucleotide. Riboflavin is involved in energy metabolism, cellular respiration, and antibody production, as well as normal growth and development.
In vitro	METHODS: Rat pancreatic islet cells were treated with Riboflavin (10 µM) for 3 days and cell viability was measured by Trypan blue assay. RESULTS: Riboflavin supplementation had no effect on the viability of HEK293T17 cells. [1] METHODS: Rainbow trout gonadal cells RTG-2 were treated with Riboflavin (10 µM) for 24 h. Islet number was measured by DTZ staining. RESULTS: Riboflavin-treated islets had modest but statistically significantly higher recovery rates of 75.2±1.6% and 69.3±2.0%, respectively. [2]
In vivo	METHODS: To investigate the effects on LPS-induced shock in mice, Riboflavin (1-10 mg/kg) was injected intraperitoneally into BALB/c mice, followed by LPS. RESULTS: High doses of Riboflavin reduced LPS-induced mortality by increasing HSP25 expression. [3]
Synonyms	Vitamin B2, E101

Chemical Properties

Molecular Weight	376.36
Formula	C₁₇H₂₀N₄O₆
Cas No.	83-88-5
Smiles	CC1=C(C)C=C2N(CC(O)C(O)C(O)CO)C3=NC(=O)NC(=O)C3=NC2=C1
Relative Density.	1.2112 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 3.77 mg/mL (10.02 mM), Sonication and heating are recommended.

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6570 mL	13.2852 mL	26.5703 mL	132.8515 mL
5 mM	0.5314 mL	2.6570 mL	5.3141 mL	26.5703 mL
10 mM	0.2657 mL	1.3285 mL	2.6570 mL	13.2852 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc