Shopping Cart

Your shopping cart is currently empty

HSR6071

Name: HSR6071
Brand: TargetMol
SKU: T11581
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T11581Cas No. 111374-21-1

HSR6071 is a novel orally active and potent anti-allergic agent with inhibitory effects on passive cutaneous anaphylaxis. HSR6071 showed anti-asthmatic activity in a rat model of experimental asthma.

HSR6071

😃Good

Purity: 99.59%

Catalog No. T11581Cas No. 111374-21-1

HSR6071 is a novel orally active and potent anti-allergic agent with inhibitory effects on passive cutaneous anaphylaxis. HSR6071 showed anti-asthmatic activity in a rat model of experimental asthma.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
2 mg	$147	5 days	5 days
5 mg	$247	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.59%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

HSR6071 is a novel orally active and potent anti-allergic agent with inhibitory effects on passive cutaneous anaphylaxis. HSR6071 showed anti-asthmatic activity in a rat model of experimental asthma.

In vivo

HSR-6071 (0.01-0.1 mg/kg; i.v.) inhibits experimental asthma induced by IgE antibody in rats in a dose-dependent manner. Additionally, HSR-6071 (0.3, 1.3 mg/kg; i.v.) prevents bronchoconstriction mediated by IgE or IgG antibody in guinea pigs. The compound inhibits cyclic AMP phosphodiesterase activity and induces relaxation of the guinea pig isolated trachea[1].With an IC50 of 0.46 nM, HSR-6071 inhibits IgE-mediated histamine release. Its effectiveness is observed not only through intravenous (i.v.) administration but also through oral (p.o.) administration in IgE-mediated passive cutaneous anaphylaxis (PCA) in rats. The most potent inhibition with HSR-6071 occurs when administered orally 5 minutes before the antigen challenge, indicating rapid absorption through the gastrointestinal tract[1].

Chemical Properties

Molecular Weight	260.26
Formula	C₁₀H₁₂N₈O
Cas No.	111374-21-1
Smiles	O=C(Nc1nnn[nH]1)c1cncc(n1)N1CCCC1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (76.85 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.8423 mL	19.2116 mL	38.4231 mL	192.1156 mL
5 mM	0.7685 mL	3.8423 mL	7.6846 mL	38.4231 mL
10 mM	0.3842 mL	1.9212 mL	3.8423 mL	19.2116 mL
20 mM	0.1921 mL	0.9606 mL	1.9212 mL	9.6058 mL
50 mM	0.0768 mL	0.3842 mL	0.7685 mL	3.8423 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

HSR-6071HSR6071HSR 6071