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Hemokinin 1 (mouse) acetate(208041-90-1 free base)
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Catalog No. TP1772L
Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.
Hemokinin 1 (mouse) acetate(208041-90-1 free base)
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Purity: 98.33%
Catalog No. TP1772L
Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $86 | In Stock | In Stock | |
| 5 mg | $247 | In Stock | In Stock | |
| 10 mg | $368 | In Stock | In Stock | |
| 25 mg | $586 | In Stock | In Stock | |
| 50 mg | $792 | In Stock | In Stock | |
| 100 mg | $1,060 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.33%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor. |
| Targets&IC50 | NK2:ki:560 nM (Human), NK1:Ki: 0.175 nM (Human), |
| In vitro | Hemokinin 1 (mouse) (1?nM-3?μM) produces concentration-dependent contraction of RUB averaging 66±3% (n=6) of the maximal contraction produced by KCl (80?mM). Hemokinin 1 (mouse) (10?nM-10?μM) induces a quickly-developing contractile responses of GPI, as does the tachykinin NK3 receptor selective agonist senktide or neurokinin B (NKB). Hemokinin 1 (mouse) induces full agonist responses but with a 500 fold lower potency as compared to NKB[1]. |
| In vivo | Hemokinin 1 (mouse) (0.01-100?nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10?nmol/kg. For systolic blood pressure (SBP), the ED50 value is 0.2?nmol/kg (0.1-0.4?nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED50 value is 0.1?nmol/kg (0.07-0.2?nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100?nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats[1]. |
| Molecular Weight | 1473.72 |
| Formula | C63H104N22O17S |
| Smiles | C[C@@H](O)[C@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCC/N=C(N)/N)=O)CO)=O)CCC/N=C(N)\N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)CC(C)C)=O)=O)CC1=CC=C(O)C=C1)=O)CC2=CC=CC=C2)=O)CCC(N)=O)=O)CCC/N=C(N)\N)=O.CC(O)=O |
| Relative Density. | no data available |
| Sequence | H-Arg-Ser-Arg-Thr-Arg-Gln-Phe-Tyr-Gly-Leu-Met-NH2. |
| Sequence Short | RSRTRQFYGLM |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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