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Boc-NH-O-C1-NHS ester

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Catalog No. T17655Cas No. 80366-85-4

Boc-NH-O-C1-NHS ester, an alkyl/ether-based PROTAC linker, is utilized in PROTAC synthesis.

Boc-NH-O-C1-NHS ester

Boc-NH-O-C1-NHS ester

🥰Excellent
Catalog No. T17655Cas No. 80366-85-4
Boc-NH-O-C1-NHS ester, an alkyl/ether-based PROTAC linker, is utilized in PROTAC synthesis.
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25 mg$29In StockIn Stock
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Batch Information

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Purity:≥98%
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COA HNMR

Product Introduction

Bioactivity
Description
Boc-NH-O-C1-NHS ester, an alkyl/ether-based PROTAC linker, is utilized in PROTAC synthesis.
In vitro
PROTACs consist of two distinct ligands connected by a linker; one binds to an E3 ubiquitin ligase, and the other targets a specific protein. They harness the intracellular ubiquitin-proteasome system for the selective degradation of target proteins[1].
Chemical Properties
Molecular Weight288.25
FormulaC11H16N2O7
Cas No.80366-85-4
SmilesCC(C)(C)OC(=O)NOCC(=O)ON1C(=O)CCC1=O
Relative Density.1.35 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mM, Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.94 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4692 mL17.3461 mL34.6921 mL173.4605 mL
5 mM0.6938 mL3.4692 mL6.9384 mL34.6921 mL
10 mM0.3469 mL1.7346 mL3.4692 mL17.3461 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PROTACLinkerPROTAC LinkersPROTAC LinkerInhibitorinhibitBoc-NH-O-C1-NHS esterBoc-NH-O-C-1-NHS esterBocNHOC1NHS esterBoc NH O C1 NHS esterAlkyl/ether
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