Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 148.00 | |
5 mg | In stock | $ 336.00 | |
10 mg | In stock | $ 497.00 | |
25 mg | In stock | $ 793.00 | |
50 mg | In stock | $ 1,130.00 | |
100 mg | In stock | $ 1,520.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 417.00 |
Description | Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect . |
In vivo | Sivopixant (S-600918) was identified as a clinical candidate with potent and selective antagonistic activity (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM) and a strong analgesic effect in the rat partial sciatic nerve ligation model (Seltzer model) of allodynia (ED50, 0.4 mg/kg). |
Synonyms | S-600918, Sivopixant |
Molecular Weight | 507.93 |
Formula | C25H22ClN5O5 |
CAS No. | 2414285-40-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (108.28 mM)
You can also refer to dose conversion for different animals. More
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Sivopixant 2414285-40-6 Membrane transporter/Ion channel Neuroscience P2X Receptor ligation analgesic S 600918 P2XRs inhibit pain Inhibitor sciatic S-600918 S600918 nerve selective inhibitor