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Anti-Bikunin/AMBP Antibody (6Y563) (Synonyms: α-1-microglobulin/bikunin precursor, UTI, ITILC, ITIL, ITI, I...)

Catalog No. TMAY-02500 Copy Product Info
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Anti-Bikunin/AMBP Antibody (6Y563) is a Mouse antibody targeting Bikunin/AMBP. Anti-Bikunin/AMBP Antibody (6Y563) can be used in ELISA.

Anti-Bikunin/AMBP Antibody (6Y563)

Copy Product Info
🥰Excellent
Catalog No. TMAY-02500
Synonyms α-1-microglobulin/bikunin precursor, UTI, ITILC, ITIL, ITI, IATIL, HI30, HCP, EDC1, alpha-1-microglobulin/bikunin precursor, A1M

Anti-Bikunin/AMBP Antibody (6Y563) is a Mouse antibody targeting Bikunin/AMBP. Anti-Bikunin/AMBP Antibody (6Y563) can be used in ELISA.

Anti-Bikunin/AMBP Antibody
(6Y563)
Pack SizePriceUSA StockGlobal StockQuantity
100 μL$1987-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-Bikunin/AMBP Antibody (6Y563) is a Mouse antibody targeting Bikunin/AMBP. Anti-Bikunin/AMBP Antibody (6Y563) can be used in ELISA.
Synonymsα-1-microglobulin/bikunin precursor, UTI, ITILC, ITIL, ITI, IATIL, HI30, HCP, EDC1, alpha-1-microglobulin/bikunin precursor, A1M
Ig Type
Mouse IgG1
Clone
6Y563
Reactivity
Human
Specificity
Human Bikunin/AMBP
Application
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Protein HC/Bikunin (rh Protein HC/Bikunin; TMPY-03044; NP_001624.1; Met1-Val203). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundThe AMBP [A1M (alpha1-microglobulin)/bikunin precursor] gene encodes two plasma glycoproteins: A1M, an immunosuppressive lipocalin, and bikunin, a member of plasma serine proteinase inhibitor family with prototypical Kunitz-type domain. Although previously believed to be constitutively expressed exclusively in liver, the present study demonstrates the induction of this gene by oxalate in porcine proximal tubular LLC-PK1 cells and rat kidney. In liver, the precursor protein is cleaved in the Golgi network by a furin-like enzyme to release constituent proteins, which undergo glycosylation before their export from the cell. In the renal tubular cells, A1M and bikunin co-precipitate, indicating lack of cleavage of the precursor protein. As the expression of the AMBP gene is regulated by A1M-specific cis elements and transcription factors, A1M protein was studied as a representative of AMBP gene expression in renal cells. The alpha(1)-microglobulin/bikunin precursor (AMBP) gene, and its two protein products were studied in mouse embryos of 8.5-15.5 days of embryonic development by in situ hybridization and immunohistochemistry. AMBP mRNA is strongly transcribed in liver parenchyma, pancreas, and intestine epithelium. Sites of weaker expression are the vessels of the umbilical cord, the developing vertebral bodies, and kidney. The alpha(1)-microglobulin and bikunin proteins are accordingly present in developing hepatocytes, pancreas, kidney, and gut. However, additional sites of protein distribution were found that do not correlate to mRNA localization: alpha(1)-microglobulin was found in myocytes and bikunin in cardiac muscle, nervous system microvasculature, and connective tissue
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human Protein HC/Bikunin Protein (TMPY-03044)
Antigen Species
Human
Biology Area
Serine Proteases and Regulators
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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