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AM-5308

Name: AM-5308
Brand: TargetMol
SKU: T63726
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63726Cas No. 2410796-89-1

Alias AM5308

AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer.

AM-5308

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Purity: 99.58%

Catalog No. T63726Alias AM5308Cas No. 2410796-89-1

AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$148	-	In Stock
5 mg	$372	-	In Stock
10 mg	$562	-	In Stock
25 mg	$1,120	-	In Stock
50 mg	$1,780	-	In Stock
100 mg	$2,880	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.58%

Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer.
In vitro	AM-5308 and AM-1882 have a favorable in vitro profile against a panel of normal cell types, which is distinct from myelosuppressive and neurotoxic anti-mitotic agents. Nevertheless, higher micromolar concentrations of AM-5308 and AM-1882 may adversely affect normal cells. [1]
In vivo	Mice with established tumors were administered vehicle, AM-1882 at 50 or 100 mg per kg or AM-5308 at 25 or 50 mg/kg daily for 18 d. AM-1882 and AM-5308 inhibited tumor growth with evidence of tumor regression. [1]
Synonyms	AM5308

Chemical Properties

Molecular Weight	529.65
Formula	C₂₆H₃₅N₅O₅S
Cas No.	2410796-89-1
Smiles	C(NC=1N=C(C=CC1)N2C[C@@H](C)OCC2)(=O)C3=C(N4CCC5(CC5)CC4)C=C(NS(CCO)(=O)=O)C=C3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (151.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8880 mL	9.4402 mL	18.8804 mL	94.4020 mL
5 mM	0.3776 mL	1.8880 mL	3.7761 mL	18.8804 mL
10 mM	0.1888 mL	0.9440 mL	1.8880 mL	9.4402 mL
20 mM	0.0944 mL	0.4720 mL	0.9440 mL	4.7201 mL
50 mM	0.0378 mL	0.1888 mL	0.3776 mL	1.8880 mL
100 mM	0.0189 mL	0.0944 mL	0.1888 mL	0.9440 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc