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Euphornin

🥰Excellent
Catalog No. T124192Cas No. 80454-47-3

Euphornin is a diterpene natural product isolated from Euphorbia dulcis that inhibits G protein-activated inwardly rectifying potassium channels GIRK1/4 (Kir3.1/3.4) with an IC50 of 2.63 µM, making it useful for studying atrial fibrillation.

Euphornin

Euphornin

🥰Excellent
Purity: 99.80%
Catalog No. T124192Cas No. 80454-47-3
Euphornin is a diterpene natural product isolated from Euphorbia dulcis that inhibits G protein-activated inwardly rectifying potassium channels GIRK1/4 (Kir3.1/3.4) with an IC50 of 2.63 µM, making it useful for studying atrial fibrillation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$64-In Stock
5 mg$129-In Stock
10 mg$213-In Stock
25 mg$455-In Stock
50 mg$655-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.80%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Euphornin is a diterpene natural product isolated from Euphorbia dulcis that inhibits G protein-activated inwardly rectifying potassium channels GIRK1/4 (Kir3.1/3.4) with an IC50 of 2.63 µM, making it useful for studying atrial fibrillation.
In vitro
Euphornin (50-200 μg/mL, 48 hours) significantly increased the expression levels of cleaved caspase-3, caspase-8, caspase-9, and caspase-10 [1].
Chemical Properties
Molecular Weight584.71
FormulaC33H44O9
Cas No.80454-47-3
Smiles[H][C@@]12\C=C(C)\[C@@H](C[C@@H](OC(C)=O)C(C)(C)\C=C\[C@H](C)[C@H](OC(C)=O)[C@@]1(O)C[C@H](C)[C@@H]2OC(=O)c1ccccc1)OC(C)=O
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80.00 mg/mL (136.82 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7102 mL8.5512 mL17.1025 mL85.5125 mL
5 mM0.3420 mL1.7102 mL3.4205 mL17.1025 mL
10 mM0.1710 mL0.8551 mL1.7102 mL8.5512 mL
20 mM0.0855 mL0.4276 mL0.8551 mL4.2756 mL
50 mM0.0342 mL0.1710 mL0.3420 mL1.7102 mL
100 mM0.0171 mL0.0855 mL0.1710 mL0.8551 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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