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PTX-35
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Catalog No. T9901A-1027 Copy Product Info
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PTX-35 is a potential first-in-class agonistic monoclonal antibody targeting Tumor Necrosis Factor Receptor Superfamily Member 25 (TNFRSF25, also known as DR3). By specifically activating the TNFRSF25 signaling pathway, the compound modulates T-cell immune responses, particularly within the tumor microenvironment. In experimental studies, PTX-35 has been demonstrated to reduce the suppressive activity of regulatory T cells (Tregs) and enhance CD4+ effector T-cell responses to tumor antigens, exhibiting significant anti-tumor potential.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | PTX-35 is a potential first-in-class agonistic monoclonal antibody targeting Tumor Necrosis Factor Receptor Superfamily Member 25 (TNFRSF25, also known as DR3). By specifically activating the TNFRSF25 signaling pathway, the compound modulates T-cell immune responses, particularly within the tumor microenvironment. In experimental studies, PTX-35 has been demonstrated to reduce the suppressive activity of regulatory T cells (Tregs) and enhance CD4+ effector T-cell responses to tumor antigens, exhibiting significant anti-tumor potential. |
| In vitro | In immunological assays, PTX-35 acted as a TNFRSF25 agonist to specifically modulate T-cell subsets, demonstrating the ability to reprogram the immune response by reducing the suppressive function of Tregs while favoring effector T-cell activation [1]. |
| In vivo | In a murine melanoma model, systemic administration of PTX-35 in the presence of tumor antigens significantly enhanced CD4+ T-cell effector responses and successfully limited the suppressive influence of regulatory T cells within the tumor site [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | DR3 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: PTX-35 chemical structure | PTX-35 in vivo | PTX-35 in vitro
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