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NBQX (Synonyms: FG9202)

Name: NBQX
Brand: TargetMol
SKU: T4113
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T4113 Copy Product Info

Purity: 99.93%

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NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.

NBQX

Copy Product Info

🥰Excellent

Catalog No. T4113

Synonyms FG9202

NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.

Cas No. 118876-58-7

Pack Size	Price	USA Stock	Global Stock
1 mg	$34	In Stock	In Stock
2 mg	$48	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$247	In Stock	In Stock
50 mg	$372	In Stock	In Stock
100 mg	$553	In Stock	In Stock
200 mg	$796	-	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.93%

Color:Yellow

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COA HNMR LCMS

Product Introduction

NBQX AI Summary

NBQX exhibits potent bioactivity related to ionotropic glutamate receptors, particularly AMPA and kainate receptors. It demonstrates high affinity for AMPA receptors with Ki values around 60.0 nM and IC50 values as low as 52.0 nM in some assays. The compound also shows moderate affinity for kainate receptors with Ki values ranging up to 4100.0 nM. It has negligible affinity for NMDA receptors and their glycine binding sites, with Ki values exceeding 100000.0 nM. In functional assays, NBQX effectively antagonizes AMPA-induced depolarizations and protects against AMPA-induced toxicity in multiple animal models, with ED50 values often below 50.0 mg/kg. Indications of neuroprotection, inhibition of Ca2+ influx in cerebellar granule cells (IC50 of 2400.0 nM), and anticonvulsant activity further underscore its therapeutic potential in modulating excitatory neurotransmission and associated neurological disorders..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
Synonyms	FG9202

Chemical Properties

Molecular Weight	336.28
Formula	C₁₂H₈N₄O₆S
Cas No.	118876-58-7
Smiles	O=C1NC2=C(NC1=O)C3=CC=CC(S(=O)(N)=O)=C3C([N+]([O-])=O)=C2
Relative Density.	1.6027 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (371.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9737 mL	14.8686 mL	29.7371 mL	148.6856 mL
5 mM	0.5947 mL	2.9737 mL	5.9474 mL	29.7371 mL
10 mM	0.2974 mL	1.4869 mL	2.9737 mL	14.8686 mL
20 mM	0.1487 mL	0.7434 mL	1.4869 mL	7.4343 mL
50 mM	0.0595 mL	0.2974 mL	0.5947 mL	2.9737 mL
100 mM	0.0297 mL	0.1487 mL	0.2974 mL	1.4869 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc