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LY450108

Name: LY450108
Brand: TargetMol
SKU: TQ0289
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TQ0289Cas No. 376594-67-1

LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.

LY450108

🥰Excellent

Purity: 99.91%

Catalog No. TQ0289Cas No. 376594-67-1

LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$37	In Stock	In Stock
10 mg	$60	In Stock	In Stock
25 mg	$103	In Stock	In Stock
50 mg	$156	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$41	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.91%

ee:97.94%

Appearance:Solid

Color:White

Resource Download

COA HNMR ORP FNMR CSFC LCMS

Product Introduction

Bioactivity

Description

LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.

Chemical Properties

Molecular Weight	396.45
Formula	C₁₉H₂₂F₂N₂O₃S
Cas No.	376594-67-1
Smiles	CC(C)S(=O)(=O)NC[C@H](C)c1ccc(NC(=O)c2cc(F)cc(F)c2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (126.12 mM), Sonication is recommended.

H2O: 1 mg/mL (2.52 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5224 mL	12.6119 mL	25.2239 mL	126.1193 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5045 mL	2.5224 mL	5.0448 mL	25.2239 mL
10 mM	0.2522 mL	1.2612 mL	2.5224 mL	12.6119 mL
20 mM	0.1261 mL	0.6306 mL	1.2612 mL	6.3060 mL
50 mM	0.0504 mL	0.2522 mL	0.5045 mL	2.5224 mL
100 mM	0.0252 mL	0.1261 mL	0.2522 mL	1.2612 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc