IL-13 Protein, Mouse, Recombinant (aa 26-131, His)

Catalog No. TMPJ-00890 Copy Product Info

IL-13 Protein, Mouse, Recombinant (aa 26-131, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 15-30 KDa and the accession number is P20109.

IL-13 Protein, Mouse, Recombinant (aa 26-131, His)

Catalog No. TMPJ-00890

Copy Product Info

IL-13 Protein, Mouse, Recombinant (aa 26-131, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 15-30 KDa and the accession number is P20109.

Pack Size	Price	USA Stock	Global Stock
5 μg	$74	7-10 days	7-10 days
10 μg	$118	In Stock	In Stock
20 μg	$187	7-10 days	7-10 days
50 μg	$350	7-10 days	7-10 days
100 μg	$618	7-10 days	7-10 days
200 μg	$1,090	7-10 days	7-10 days
500 μg	$2,360	7-10 days	7-10 days
1 mg	$3,790	7-10 days	7-10 days

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In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Information

Biological Activity	Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 2-13 ng/ml. (QC verified)
Description	IL-13 Protein, Mouse, Recombinant (aa 26-131, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 15-30 KDa and the accession number is P20109.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	P20109
Synonyms	T-Cell Activation Protein P600,Interleukin-13,IL-13,Il13
Amino Acid	Ser26-Phe131
Construction	Ser26-Phe131
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
Molecular Weight	15-30 KDa (reducing condition)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.