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Anti-CD155/PVR Antibody (7L672)
😃Good
Catalog No. TMAH-01026
Alias Tage4, PVSFLJ25946, PVS, PVR, nectin-like 5, Necl-5, NECL5, HVED, FLJ25946, CD155
Anti-CD155/PVR Antibody (7L672) is an antibody targeting CD155/PVR. Anti-CD155/PVR Antibody (7L672) can be used in ELISA,IHC,WB.
Anti-CD155/PVR Antibody (7L672)
Anti-CD155/PVR Antibody (7L672)
😃Good
Catalog No. TMAH-01026Alias Tage4, PVSFLJ25946, PVS, PVR, nectin-like 5, Necl-5, NECL5, HVED, FLJ25946, CD155
Anti-CD155/PVR Antibody (7L672) is an antibody targeting CD155/PVR. Anti-CD155/PVR Antibody (7L672) can be used in ELISA,IHC,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $207 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD155/PVR Antibody (7L672) is an antibody targeting CD155/PVR. Anti-CD155/PVR Antibody (7L672) can be used in ELISA,IHC,WB. |
| Synonyms | Tage4, PVSFLJ25946, PVS, PVR, nectin-like 5, Necl-5, NECL5, HVED, FLJ25946, CD155 |
| Ig Type | Rabbit IgG |
| Clone | 7L672 |
| Reactivity | Human |
| Verified Activity | 1. Western Blot -Positive WB detected in: A549 whole cell lysate -All lanes: Poliovirus Receptor antibody at 1:500 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 70 kDa -Observed band size: 70 kDa 2. IHC image of TMAH-01026 diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.42% DAB. |
| Application | |
| Recommended Dose | WB:1:500-1:2000; IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Delta]: Cell membrane; Single-pass type I membrane protein.; [Isoform Beta]: Secreted.; [Isoform Gamma]: Secreted. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. (Microbial infection) Acts as a receptor for Pseudorabies virus. (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human PVR |
| Antigen Species | Human |
| Gene Name | PVR |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Microbiology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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