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Anti-CD155/PVR Antibody (7L672)

😃Good
Catalog No. TMAH-01026
Alias Tage4, PVSFLJ25946, PVS, PVR, nectin-like 5, Necl-5, NECL5, HVED, FLJ25946, CD155

Anti-CD155/PVR Antibody (7L672) is an antibody targeting CD155/PVR. Anti-CD155/PVR Antibody (7L672) can be used in ELISA, WB, IHC.

Anti-CD155/PVR Antibody (7L672)

Anti-CD155/PVR Antibody (7L672)

😃Good
Catalog No. TMAH-01026Alias Tage4, PVSFLJ25946, PVS, PVR, nectin-like 5, Necl-5, NECL5, HVED, FLJ25946, CD155
Anti-CD155/PVR Antibody (7L672) is an antibody targeting CD155/PVR. Anti-CD155/PVR Antibody (7L672) can be used in ELISA, WB, IHC.
Pack SizePriceAvailabilityQuantity
50 μL$207 7-10 days
100 μL$349 7-10 days
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Product Introduction

Bioactivity
Description
Anti-CD155/PVR Antibody (7L672) is an antibody targeting CD155/PVR. Anti-CD155/PVR Antibody (7L672) can be used in ELISA, WB, IHC.
AliasTage4, PVSFLJ25946, PVS, PVR, nectin-like 5, Necl-5, NECL5, HVED, FLJ25946, CD155
Ig Type
Rabbit IgG
Clone
7L672
Reactivity
Human
Verified Activity
1. Western Blot
-Positive WB detected in: A549 whole cell lysate
-All lanes: Poliovirus Receptor antibody at 1:500
-Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
-Predicted band size: 70 kDa
-Observed band size: 70 kDa
2. IHC image of TMAH-01026 diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.42% DAB.
Application
ELISA, WB, IHC
Recommended Dose
WB:1:500-1:2000; IHC:1:50-1:200.
Antibody Type
Monoclonal
Subcellular Localization[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Delta]: Cell membrane; Single-pass type I membrane protein.; [Isoform Beta]: Secreted.; [Isoform Gamma]: Secreted.
ConstructionRecombinant Antibody
PurificationAffinity-chromatography
AppearanceLiquid
FormulationPhosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundMediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. (Microbial infection) Acts as a receptor for Pseudorabies virus. (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
A synthetic peptide: Human PVR
Antigen Species
Human
Gene ID
5817
Uniprot ID
Biology Area
Microbiology
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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